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  1. Research

    Chronic cigarette smoking is linked with structural alterations in brain regions showing acute nicotinic drug-induced functional modulations

    Whereas acute nicotine administration alters brain function which may, in turn, contribute to enhanced attention and performance, chronic cigarette smoking is linked with regional brain atrophy and poorer cogn...

    Matthew T. Sutherland, Michael C. Riedel, Jessica S. Flannery, Julio A. Yanes, Peter T. Fox, Elliot A. Stein and Angela R. Laird

    Behavioral and Brain Functions 2016 12:16

    Published on: 2 June 2016

  2. Review

    Safety out of control: dopamine and defence

    We enjoy a sophisticated understanding of how animals learn to predict appetitive outcomes and direct their behaviour accordingly. This encompasses well-defined learning algorithms and details of how these mig...

    Kevin Lloyd and Peter Dayan

    Behavioral and Brain Functions 2016 12:15

    Published on: 23 May 2016

  3. Research

    Oral administration of potassium bromate induces neurobehavioral changes, alters cerebral neurotransmitters level and impairs brain tissue of swiss mice

    Potassium bromate (KBrO3) is widely used as a food additive and is a major water disinfection by-product. The present study reports the side effects of KBrO3 administration on the brain functions and behaviour of...

    Jamaan Ajarem, Naif G. Altoom, Ahmed A. Allam, Saleh N. Maodaa, Mostafa A. Abdel- Maksoud and Billy KC. Chow

    Behavioral and Brain Functions 2016 12:14

    Published on: 12 May 2016

  4. Research

    Involvement of hippocampal acetylcholinergic receptors in electroacupuncture analgesia in neuropathic pain rats

    Cumulating evidence has shown a close correlation between electroacupuncture stimulation (EAS) frequency-specific analgesic effect and central opioid peptides. However, the actions of hippocampal acetylcholine...

    Shu Ping Chen, Yu Kan, Jian Liang Zhang, Jun Ying Wang, Yong Hui Gao, Li Na Qiao, Xiu Mei Feng, Ya Xia Yan and Jun Ling Liu

    Behavioral and Brain Functions 2016 12:13

    Published on: 12 April 2016

  5. Research

    Neuropsychological and neurophysiological benefits from white noise in children with and without ADHD

    Optimal stimulation theory and moderate brain arousal (MBA) model hypothesize that extra-task stimulation (e.g. white noise) could improve cognitive functions of children with attention-deficit/hyperactivity d...

    Simon Baijot, Hichem Slama, Göran Söderlund, Bernard Dan, Paul Deltenre, Cécile Colin and Nicolas Deconinck

    Behavioral and Brain Functions 2016 12:11

    Published on: 15 March 2016

  6. Research

    Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) improves brain ischemia-induced pulmonary injury in rats associated to TNF-α expression

    Bone marrow mesenchymal stem cell (BMSCs)-based therapy seems to be a promising treatment for acute lung injury, but the therapeutic effects of BMSCs transplantation on acute lung injury induced by brain ische...

    Qin-qin He, Xiang He, Yan-ping Wang, Yu Zou, Qing-jie Xia, Liu-Lin Xiong, Chao-zhi Luo, Xiao-song Hu, Jia Liu and Ting-hua Wang

    Behavioral and Brain Functions 2016 12:9

    Published on: 1 March 2016

  7. Research

    Acute immobilization stress following contextual fear conditioning reduces fear memory: timing is essential

    Histone acetylation is regulated in response to stress and plays an important role in learning and memory. Chronic stress is known to deteriorate cognition, whereas acute stress facilitates memory formation. H...

    Akemi Uwaya, Hyunjin Lee, Jonghyuk Park, Hosung Lee, Junko Muto, Sanae Nakajima, Shigeo Ohta and Toshio Mikami

    Behavioral and Brain Functions 2016 12:8

    Published on: 24 February 2016

  8. Research

    Non-targeted metabolite profiling reveals changes in oxidative stress, tryptophan and lipid metabolisms in fearful dogs

    Anxieties, such as shyness, noise phobia and separation anxiety, are common but poorly understood behavioural problems in domestic dogs, Canis familiaris. Although studies have demonstrated genetic and environmen...

    Jenni Puurunen, Katriina Tiira, Marko Lehtonen, Kati Hanhineva and Hannes Lohi

    Behavioral and Brain Functions 2016 12:7

    Published on: 12 February 2016

  9. Research

    Effect of parsley (Petroselinum crispum, Apiaceae) juice against cadmium neurotoxicity in albino mice (Mus Musculus)

    Parsley was employed as an experimental probe to prevent the behavioral, biochemical and morphological changes in the brain tissue of the albino mice following chronic cadmium (Cd) administration.

    Saleh N. Maodaa, Ahmed A. Allam, Jamaan Ajarem, Mostafa A. Abdel-Maksoud, Gadah I. Al-Basher and Zun Yao Wang

    Behavioral and Brain Functions 2016 12:6

    Published on: 4 February 2016

  10. Research

    Gonadectomy reduces the density of androgen receptor-immunoreactive neurons in male rat’s hippocampus: testosterone replacement compensates it

    In the present study, the role of gonadectomy on memory impairment and the density of androgen receptor-immunoreactive neurons in rats’ hippocampus as well as the ability of testosterone to compensate of memo...

    Sajjad Moghadami, Mehrdad Jahanshahi, Hamid Sepehri and Hossein Amini

    Behavioral and Brain Functions 2016 12:5

    Published on: 28 January 2016

  11. Research

    Attention deficit hyperactivity disorder: genetic association study in a cohort of Spanish children

    Attention deficit hyperactivity disorder (ADHD) has a strong genetic component. The study is aimed to test the association of 34 polymorphisms with ADHD symptomatology considering the role of clinical subtypes...

    Clara I. Gomez-Sanchez, Rosa Riveiro-Alvarez, Victor Soto-Insuga, Maria Rodrigo, Pilar Tirado-Requero, Ignacio Mahillo-Fernandez, Francisco Abad-Santos, Juan J. Carballo, Rafael Dal-Ré and Carmen Ayuso

    Behavioral and Brain Functions 2016 12:2

    Published on: 8 January 2016

  12. Research

    Long-term influence of recurrent acute otitis media on neural involuntary attention switching in 2-year-old children

    A large group of young children are exposed to repetitive middle ear infections but the effects of the fluctuating hearing sensations on immature central auditory system are not fully understood. The present s...

    Sini Haapala, Elina Niemitalo-Haapola, Antti Raappana, Tiia Kujala, Kalervo Suominen, Eira Jansson-Verkasalo and Teija Kujala

    Behavioral and Brain Functions 2016 12:1

    Published on: 4 January 2016

  13. Research

    Feasibility of focal cerebral ischemia and reperfusion surgery combined with chronic unpredictable mild stress to simulate the post-stroke depressive state in rats

    To evaluate the feasibility of focal cerebral ischemia and reperfusion (FCIR) surgery combined chronic unpredictable mild stress (CUMS) to simulate the post-stroke depression (PSD) state in rats.

    Lingchuan Niu, LiXinhao Jin, Yanhong Zhang, Bing Liu and Changqing Li

    Behavioral and Brain Functions 2015 11:39

    Published on: 24 December 2015

    The Erratum to this article has been published in Behavioral and Brain Functions 2016 12:4

  14. Research

    Multivariable analysis to determine if HIV-1 Tat dicysteine motif is associated with neurodevelopmental delay in HIV-infected children in Malawi

    HIV-1 Tat protein is implicated in HIV-neuropathogenesis. Tat C31S polymorphism (TatCS) has been associated with milder neuropathology in vitro and in animal models but this has not been addressed in a cohort of ...

    Jasmeen Dara, Anna Dow, Elizabeth Cromwell, Christa Buckheit Sturdevant, Macpherson Mallewa, Ronald Swanstrom, Annelies Van Rie and Vinayaka R. Prasad

    Behavioral and Brain Functions 2015 11:38

    Published on: 17 December 2015

  15. Research

    Decreased functional connectivity between ventral tegmental area and nucleus accumbens in Internet gaming disorder: evidence from resting state functional magnetic resonance imaging

    Internet gaming disorder (IGD) has become an increasing mental health problem worldwide. Decreased resting-state functional connectivity (rsFC) between the ventral tegmental area (VTA) and the nucleus accumben...

    Jin-Tao Zhang, Shan-Shan Ma, Sarah W. Yip, Ling-Jiao Wang, Chao Chen, Chao-Gan Yan, Lu Liu, Ben Liu, Lin-Yuan Deng, Qin-Xue Liu and Xiao-Yi Fang

    Behavioral and Brain Functions 2015 11:37

    Published on: 18 November 2015

  16. Research

    Serum concentrations of kynurenines in adult patients with attention-deficit hyperactivity disorder (ADHD): a case–control study

    The essential amino acid tryptophan is catabolised mainly through the kynurenine pathway. Altered circulating levels of kynurenines have been reported in chronic inflammatory conditions and in several neuropsy...

    Tore Ivar Malmei Aarsland, Elisabeth Toverud Landaas, Tor-Arne Hegvik, Arve Ulvik, Anne Halmøy, Per Magne Ueland and Jan Haavik

    Behavioral and Brain Functions 2015 11:36

    Published on: 5 November 2015

  17. Research

    Fibroblast growth factor 8 regulates postnatal development of paraventricular nucleus neuroendocrine cells

    Fibroblast growth factors (FGFs) are crucial signaling molecules that direct the development of the vertebrate brain. FGF8 gene signaling in particular, may be important for the development of the hypothalamus...

    Karla M. Rodriguez, Erica L. Stevenson, Courtney E. Stewart, Megan L. Linscott and Wilson C. J. Chung

    Behavioral and Brain Functions 2015 11:34

    Published on: 4 November 2015

  18. Research

    Lipopolysaccharide exacerbates infarct size and results in worsened post-stroke behavioral outcomes

    A third of ischemic stroke cases have no traditional underlying causes such as hypertension, diabetes, atherosclerosis, obesity, or age. Moreover, thirty to forty percent of strokes occur during or acutely aft...

    Danielle N. Doll, Elizabeth B. Engler-Chiurazzi, Sara E. Lewis, Heng Hu, Ashley E. Kerr, Xuefang Ren and James W. Simpkins

    Behavioral and Brain Functions 2015 11:32

    Published on: 13 October 2015

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