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Table 1 Allele frequencies

From: COMT genetic variation confers risk for psychotic and affective disorders: a case control study

   All affecteds* SCZ + SA
SNP ID (dbSNP No) Alleles (major/minor) * MAF Controls MAF Cases p-value Trend p-value OR (95%CI) MAF Controls MAF Cases p-value Trend p-value OR (95%CI)
   n = 467 n = 394     n = 467 n = 258    
rs2097063 (287A/G) A/G 0.414 0.346 0.004 0.006 1.34 (1.10, 1.64) 0.414 0.347 0.015 0.019 1.33 (1.06, 1.67)
rs737865 T/C 0.309 0.332 0.315 0.321 1.11 (0.90, 1.37) 0.309 0.329 0.438 0.448 1.10 (0.87, 1.39)
rs4680 (Val/Met) A/G 0.475 0.524 0.050 0.048 1.21 (1.00, 1.47) 0.475 0.504 0.304 0.299 1.12 (0.90, 1.40)
rs165599 A/G 0.326 0.376 0.035 0.040 1.25 (1.02, 1.53) 0.326 0.364 0.160 0.175 1.18 (0.94, 1.49)
   SCZ Affective disorder*
SNP ID (dbSNP No) Alleles (major/minor) * MAF Controls MAF Cases p-value Trend p-value OR (95%CI) MAF Controls MAF Cases p-value Trend p-value OR (95%CI)
   n = 467 n = 196     n = 467 n = 112    
rs2097063 (287A/G) A/G 0.414 0.338 0.011 0.014 1.39 (1.08, 1.79) 0.414 0.346 0.062 0.067 1.34 (0.98, 1.82)
rs737865 T/C 0.309 0.327 0.511 0.518 1.09 (0.84, 1.41) 0.309 0.329 0.560 0.556 1.10 (0.80, 1.50)
rs4680 (Val/Met) A/G 0.475 0.500 0.419 0.414 1.10 (0.87, 1.41) 0.475 0.565 0.018 0.015 1.43 (1.06, 1.93)
rs165599 A/G 0.326 0.362 0.221 0.240 1.17 (0.91, 1.51) 0.326 0.400 0.039 0.043 1.38 (1.02, 1.87)
   Major depressive disorder BP
SNP ID (dbSNP No) Alleles (major/minor) * MAF Controls MAF Cases p-value Trend p-value OR (95%CI) MAF Controls MAF Cases p-value Trend p-value OR (95%CI)
   n = 467 n = 30     n = 467 n = 82    
rs2097063 (287A/G) A/G 0.414 0.283 0.046 0.049 1.79 (1.01, 3.18) 0.414 0.369 0.280 0.290 1.21 (0.86, 1.71)
rs737865 T/C 0.309 0.333 0.688 0.689 1.12 (0.64, 1.95) 0.309 0.327 0.638 0.634 1.09 (0.76, 1.56)
rs4680 (Val/Met) A/G 0.475 0.586 0.101 0.093 1.56 (0.91, 2.68) 0.475 0.557 0.058 0.050 1.39 (0.99, 1.95)
rs165599 A/G 0.326 0.414 0.169 0.184 1.46 (0.85, 2.51) 0.326 0.395 0.088 0.095 1.35 (0.96, 1.91)
  1. * All Affecteds: SCZ (schizophrenia), SA (schizoaffective disorder), BP (bipolar disorder), Major depressive disorder, psychotic disorder NOS, depressive disorder NOS
  2. * Affective Disorder: Bipolar disorder and major depressive disorder