COMT genetic variation confers risk for psychotic and affective disorders: a case control study

Funke, Birgit; Malhotra, Anil K; Finn, Christine T; Plocik, Alex M; Lake, Stephen L; Lencz, Todd; DeRosse, Pamela; Kane, John M; Kucherlapati, Raju

doi:10.1186/1744-9081-1-19

Behavioral and Brain Functions

Table 1 Allele frequencies

From: COMT genetic variation confers risk for psychotic and affective disorders: a case control study

		All affecteds*					SCZ + SA
SNP ID (dbSNP No)	Alleles (major/minor) *	MAF Controls	MAF Cases	p-value	Trend p-value	OR (95%CI)	MAF Controls	MAF Cases	p-value	Trend p-value	OR (95%CI)
		n = 467	n = 394				n = 467	n = 258
rs2097063 (287A/G)	A/G	0.414	0.346	*0.004*	*0.006*	1.34 (1.10, 1.64)	0.414	0.347	*0.015*	*0.019*	1.33 (1.06, 1.67)
rs737865	T/C	0.309	0.332	0.315	0.321	1.11 (0.90, 1.37)	0.309	0.329	0.438	0.448	1.10 (0.87, 1.39)
rs4680 (Val/Met)	A/G	0.475	0.524	*0.050*	*0.048*	1.21 (1.00, 1.47)	0.475	0.504	0.304	0.299	1.12 (0.90, 1.40)
rs165599	A/G	0.326	0.376	*0.035*	*0.040*	1.25 (1.02, 1.53)	0.326	0.364	0.160	0.175	1.18 (0.94, 1.49)
		SCZ					Affective disorder*
SNP ID (dbSNP No)	Alleles (major/minor) *	MAF Controls	MAF Cases	p-value	Trend p-value	OR (95%CI)	MAF Controls	MAF Cases	p-value	Trend p-value	OR (95%CI)
		n = 467	n = 196				n = 467	n = 112
rs2097063 (287A/G)	A/G	0.414	0.338	*0.011*	*0.014*	1.39 (1.08, 1.79)	0.414	0.346	0.062	0.067	1.34 (0.98, 1.82)
rs737865	T/C	0.309	0.327	0.511	0.518	1.09 (0.84, 1.41)	0.309	0.329	0.560	0.556	1.10 (0.80, 1.50)
rs4680 (Val/Met)	A/G	0.475	0.500	0.419	0.414	1.10 (0.87, 1.41)	0.475	0.565	*0.018*	*0.015*	1.43 (1.06, 1.93)
rs165599	A/G	0.326	0.362	0.221	0.240	1.17 (0.91, 1.51)	0.326	0.400	*0.039*	*0.043*	1.38 (1.02, 1.87)
		Major depressive disorder					BP
SNP ID (dbSNP No)	Alleles (major/minor) *	MAF Controls	MAF Cases	p-value	Trend p-value	OR (95%CI)	MAF Controls	MAF Cases	p-value	Trend p-value	OR (95%CI)
		n = 467	n = 30				n = 467	n = 82
rs2097063 (287A/G)	A/G	0.414	0.283	*0.046*	*0.049*	1.79 (1.01, 3.18)	0.414	0.369	0.280	0.290	1.21 (0.86, 1.71)
rs737865	T/C	0.309	0.333	0.688	0.689	1.12 (0.64, 1.95)	0.309	0.327	0.638	0.634	1.09 (0.76, 1.56)
rs4680 (Val/Met)	A/G	0.475	0.586	0.101	0.093	1.56 (0.91, 2.68)	0.475	0.557	*0.058*	*0.050*	1.39 (0.99, 1.95)
rs165599	A/G	0.326	0.414	0.169	0.184	1.46 (0.85, 2.51)	0.326	0.395	0.088	0.095	1.35 (0.96, 1.91)

* All Affecteds: SCZ (schizophrenia), SA (schizoaffective disorder), BP (bipolar disorder), Major depressive disorder, psychotic disorder NOS, depressive disorder NOS
* Affective Disorder: Bipolar disorder and major depressive disorder

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ISSN: 1744-9081

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