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Table 2 Differentially expressed genes in the prefrontal cortex (PFC) of cohort 2 SHRs relative to controls

From: Prefrontal cortical and striatal transcriptional responses to the reinforcing effect of repeated methylphenidate treatment in the spontaneously hypertensive rat, animal model of attention-deficit/hyperactivity disorder (ADHD)

A. Upregulated genes

   

Probe set ID

Gene title

Gene symbol

Mean fold change

 

Regulation of apoptosis

  

1388924_at

Angiopoietin-like 4

Angptl4

1.78

1389538_at

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

Nfkbia

1.66

1387125_at

S100 calcium binding protein A9

S100a9

4.37

1373302_at

Alkaline ceramidase 2

Acer2

2.27

1391791_at

Alkaline ceramidase 2

Acer2

1.87

 

Transcription

  

1387087_at

CCAAT/enhancer binding protein (C/EBP), beta

Cebpb

1.78

1387874_at

D site of albumin promoter (albumin D-box) binding protein

Dbp

2.18

1378745_at

Period homolog 3 (Drosophila)

Per3

1.68

 

Protein complex assembly

  

1389234_at

Von Willebrand factor

Vwf

2.17

1367553_x_at

Hemoglobin, beta /// beta globin minor gene /// beta-globin

Hbb /// LOC100134871 /// LOC689064

2.82

1370239_at

Hemoglobin alpha, adult chain 2 /// hemoglobin alpha 2 chain

Hba-a2 /// LOC360504

1.86

1370240_x_at

Hemoglobin alpha, adult chain 2 /// hemoglobin alpha 2 chain

Hba-a2 /// LOC360504

1.86

 

Cell migration

  

1398265_at

ATP-binding cassette, subfamily C (CFTR/MRP), member 9

Abcc9

1.81

1367631_at

Connective tissue growth factor

Ctgf

1.68

 

Miscellaneous

  

1371237_a_at

Metallothionein 1a /// transthyretin

Mt1a /// Ttr

1.69

1371447_at

Placenta-specific 8

Plac8

1.80

1384969_at

Collagen, type XXIV, alpha 1

Col24a1

1.70

1387658_at

Eukaryotic elongation factor-2 kinase

Eef2k

1.69

1379766_at

---

---

1.66

1381178_at

---

---

2.15

1386145_at

---

---

2.23

1389250_at

---

---

1.71

B. Downregulated genes

   

1370454_at

Homer homolog 1 (Drosophila)

Homer1

0.37

1370997_at

Homer homolog 1 (Drosophila)

Homer1

0.46

1380545_at

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

Asap1

0.58

1393324_at

Junctional adhesion molecule 2

Jam2

0.55

1393451_at

Centromere protein N

Cenpn

0.54

1395309_at

---

---

0.60

1378507_at

---

---

0.58

1384410_at

---

---

0.59