Haplotype rs2760157-rs807507 associated with onset detection score. (A) The most significant SNPs, rs2760157 and rs807507, found in single-marker quantitative analyses (onset detection) were used for haplotype analyses. The haplotypes are significantly associated with onset detection. C-C haplotype is the risk haplotype with -0.399 AddVal (95% CI = -0.7102 to -0.0878). (B) Plot of possible haplotypes found in each individual shows a decreasing trend of onset detection score for person carrying C-C haplotype. (C) The onset detection score of C-C carriers is significantly different from non-C-C carriers.