Linkage disequilibrium plots of SNPs located in KIAA0319. (A) Inter-SNP linkage disequilibrium was generated for studied markers covering KIAA0319 using Haploview 4.0 . Color scheme represents the r2 value (stronger linkage disequilibrium is shown using progressively darker shading). Schematic diagram of KIAA0319 and TDP2 genes obtained from Ensembl (http://www.ensembl.org). Right bottom: Linkage disequilibrium plots of the significant haplotype rs2760157-rs807507 (Red box) found in this study (Hong Kong sample) and the haplotype rs4504469-2038137-2143340 (Blue box) studied in Paracchini et al. (UK sample) . Linkage disequilibrium plot represent D’ measure was also generated. The cells are color in red gradually representing strength of LD between the two markers: Bright red (LOD ≥ 2 D’ = 1), pink red (LOD ≥ 2 D’ < 1) and white color for no or weak LD (LOD < 2, D’ < 1). (B) Regional LD plots in KIAA0319 5′ and TTRAP (TDP2) genomic region (plots were generated using SNAP web-based software at the Broad Institute  and data from 1000 Genomes Project Pilot 1). r2 value relative to rs2038137 and rs2143340 (indicated by blue arrows) in CEU and CHBJPT populations for SNP in a 100Kb window around it plotted against their genomic location. Dotted vertical lines delimit regions including SNPs with r2 > 0.5. Size and color intensity of markers are proportional to r2 values.