Skip to main content

Table 1 SNPs nominally associated with CSF HVA concentrations in psychotic patients

From: Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosis

 

Patients with psychosis (n = 74; 45 men, 29 women)

Healthy controls (n = 111; 63 men, 48 women)

HVA mean (S.D.)

178.6 (79.3) nmol/l

167.5 (68.4) nmol/l

Gene

SNP

MAF(%)

HWE

P

MAF(%)

HWE

P

DDC

rs11238133

36

0.211

0.004

41

1.000

0.757

DDC

rs6951648

19

0.273

0.005

17

0.735

0.297

DDC

rs10499696

11

0.186

0.009

9

0.594

0.681

DDC

rs921451

42

0.018

0.011

43

0.564

0.661

DDC

rs9942686

21

0.723

0.017

23

1.000

0.305

TH

rs10770141

33

0.608

0.023

40

1.000

0.433

TPH1

rs211105

31

0.785

0.029

25

0.449

0.292

TH

rs10840491

16

0.680

0.035

12

0.640

0.433

DDC

rs6593011

15

0.652

0.038

13

0.208

0.959

COMT

rs165774

32

0.003

0.043

30

0.258

0.650

TPH2

rs1872824

34

0.606

0.047

33

0.830

0.685

TH

rs10840489

18

1.000

0.048

14

1.000

0.357

  1. Minor allele frequencies (MAF), p-values of testing for Hardy–Weinberg equilibrium (HWE) and p-values (P) from multiple linear regressions of single nucleotide polymorphisms (SNPs) nominally associated with homovanillic acid (HVA) concentrations in the cerebrospinal fluid of psychotic patients and the corresponding association statistics among healthy controls.