Polymorphisms in genes implicated in dopamine, serotonin and noradrenalin metabolism suggest association with cerebrospinal fluid monoamine metabolite concentrations in psychosis

Table 2 SNPs nominally associated with CSF 5-HIAA concentrations in psychotic patients

		Patients with psychosis (n = 74; 45 men, 29 women)			Healthy controls (n = 111; 63 men, 48 women)
5-HIAA mean (S.D.)		93.1 (34) nmol/l			90.8 (36.2) nmol/l
Gene	SNP	MAF (%)	HWE	P	MAF (%)	HWE	P
MAOB(women)	rs2311013	3	1.000	0.009	4	1.000	0.866
MAOB(women)	rs1181252	3	1.000	0.009	4	1.000	0.053
DDC	rs9942686	21	0.723	0.009	23	1.000	0.069
DDC	rs11238133	36	0.211	0.012	41	1.000	0.516
DBH	rs1611118	7	1.000	0.014	7	0.397	0.895
DDC	rs11238131	30	0.784	0.019	32	0.826	0.829
MAOA (men)	rs5906957	31		0.027	17		0.089
DDC	rs11575535	4	1.000	0.035	4	1.000	0.302
TPH1	rs1799913	42	0.096	0.039	41	0.334	0.330
DBH	rs6271	3	1.000	0.047	5	1.000	0.528
MAOA (men)	rs4301558	36		0.048	20		0.123
MAOA (men)	rs3027396	36		0.048	21		0.299

Minor allele frequencies (MAF), p-values of testing for Hardy–Weinberg equilibrium (HWE) and p-values (P) from multiple linear regressions of single nucleotide polymorphisms (SNPs) nominally associated with 5-hydroxyindoleacetic acid (5-HIAA) concentrations in the cerebrospinal fluid of psychotic patients and the corresponding association statistics among healthy controls. MAOA and MAOB are located on chromosome X and the analyses were therefore conducted separately for men and women.

ISSN: 1744-9081