Figure 1
From: A matter of timing: harm reduction in learned helplessness
Reanalysis of data from 163 congenitally helpless (cLH, n = 88) and non-helpless rats (cNLH, n = 75). A: All rats have been tested for learned helplessness at the age of nine or ten weeks to confirm the helpless or non-helpless phenotype in the escape paradigm. The test consisted of 15 trials in which an electric foot shock (0.8 mA, 60 s) could be terminated by the animals pressing a bar. Latency until pressing the lever is given separately for the strains as means ± SEM. As indicated by the red box, the latency difference between cLH and cNLH was most pronounced between trials 3 to 6. B and C: Receiver Operating Characteristic (ROC)-curves: In a ROC-curve the true positive rate (sensitivity) is plotted in function of the false positive rate (100-specificity). A test with perfect discrimination (no overlap between the two distributions) has a ROC-curve that passes through the upper left corner (100% sensitivity, 100% specificity). Therefore the closer the ROC curve is to the upper left corner, the higher the overall accuracy of the test [14]. Latency measurements of trials 3 to 6 classified cLH and cNLH rats with at least the same sensitivity and specificity as being helpless or non-helpless as trials 1 to 15 did.