Comparison of spontaneous locomotor activity in the open field. (A) Distance traveled in 5 min bins during spontaneous locomotion by Disc1 L100P/L100P mutants (n = 20), L100P/+ mutants (n = 18), and wild-type (+/+) littermates (n = 20). Repeated measures ANOVA revealed no significant genotype × time interaction. Data are expressed as mean ± SEM. (B) Total distance traveled over 90 min. ANOVA revealed no significant main effect of genotype. Data are expressed as mean ± SEM.