Figure 2From: Effects of background mutations and single nucleotide polymorphisms (SNPs) on the Disc1 L100P behavioral phenotype associated with schizophrenia in miceEffect of methamphetamine on locomotor activity in the open field. (A–D) Distance traveled in 5 min bins following methamphetamine or saline treatment. Repeated measures ANOVA revealed no significant genotype × time interactions among Disc1 L100P/L100P (n = 11–12), L100P/+ (n = 11–13), and +/+ littermates (n = 8–9). Data are expressed as mean ± SEM. (E) Total distance traveled during 30 min before drug injection. ANOVA revealed no significant genotype × drug interaction or a main effect of genotype. (F) Total distance traveled during 60 min after drug injection. ANOVA revealed a significant main effect of the drug. Methamphetamine elicited hyperlocomotion in a dose-dependent manner in all three genotypes. (G, H) Effect of methamphetamine on the locomotor activity of inbred C57BL/6 J mice and +/+ littermates derived from Disc1 L100P mutant line in the open field. (G) Total distance traveled for 30 min before drug injection. ANOVA revealed no significant genetic background × drug interaction or a main effect of genetic background. (H) Total distance traveled over 60 min after drug injection. ANOVA revealed a significant main effect of drug. Methamphetamine elicited hyperlocomotion in a dose-dependent manner in both two groups. L100P line +/+ in (G, H) and +/+ in (E, F) were the same mice for each treatment group. Data are expressed as mean ± SEM. **p < 0.01 or ***p < 0.001 compared with the saline-treated group.Back to article page