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Figure 2 | Behavioral and Brain Functions

Figure 2

From: Effects of background mutations and single nucleotide polymorphisms (SNPs) on the Disc1 L100P behavioral phenotype associated with schizophrenia in mice

Figure 2

Effect of methamphetamine on locomotor activity in the open field. (A–D) Distance traveled in 5 min bins following methamphetamine or saline treatment. Repeated measures ANOVA revealed no significant genotype × time interactions among Disc1 L100P/L100P (n = 11–12), L100P/+ (n = 11–13), and +/+ littermates (n = 8–9). Data are expressed as mean ± SEM. (E) Total distance traveled during 30 min before drug injection. ANOVA revealed no significant genotype × drug interaction or a main effect of genotype. (F) Total distance traveled during 60 min after drug injection. ANOVA revealed a significant main effect of the drug. Methamphetamine elicited hyperlocomotion in a dose-dependent manner in all three genotypes. (G, H) Effect of methamphetamine on the locomotor activity of inbred C57BL/6 J mice and +/+ littermates derived from Disc1 L100P mutant line in the open field. (G) Total distance traveled for 30 min before drug injection. ANOVA revealed no significant genetic background × drug interaction or a main effect of genetic background. (H) Total distance traveled over 60 min after drug injection. ANOVA revealed a significant main effect of drug. Methamphetamine elicited hyperlocomotion in a dose-dependent manner in both two groups. L100P line +/+ in (G, H) and +/+ in (E, F) were the same mice for each treatment group. Data are expressed as mean ± SEM. **p < 0.01 or ***p < 0.001 compared with the saline-treated group.

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