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Table 1 Schedule of Drug Treatment

From: Chronic exposure to MDMA (Ecstasy) elicits behavioral sensitization in rats but fails to induce cross-sensitization to other psychostimulants

Experimental Day Day 1 Days 2–7 Days 8–12 Day 13 Day 14 Days 15–37 Day 37 Day 39
Sal Group (N = 9) Saline Saline Washout 5.0 mg/kg MDMA Amph Washout Saline Amph/MPD
2.5 Group (N = 9) Saline 2.5 mg/kg MDMA Washout 2.5 mg/kg MDMA Amph Washout Saline Amph/MPD
5.0 Group (N = 9) Saline 5.0 mg/kg MDMA Washout 5.0 mg/kg MDMA Amph Washout Saline Amph/MPD
10.0 Group (N = 9) Saline 10.0 mg/kg MDMA Washout 10.0 mg/kg MDMA Amph Washout Saline Amph/MPD
  1. shows the schedule of drug treatment for the four experimental groups. Locomotor activity was recorded on experimental Days 1–7, 12–14, 37–39. The numbers in the first column (2.5, 5.0, and 10.0) refer to MDMA doses (i.p.). Amph = 0.6 mg/kg amphetamine. Amph/MPD: On experimental Day 39, animals in each group were given either 2.5 mg/kg methylphenidate (N = 3/group) or 0.6 mg/kg amphetamine (N = 6/group).