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Table 2 Distributions of the genotype frequencies of the APOE gene variations in European-American subjects

From: Variation at APOE and STH loci and Alzheimer's disease

  APOE genotypes Exact P-values
  ε 2/ε 3 ε 2/ε 4 ε 3/ε 3 ε 3/ε 4 ε 4/ε 4 Total ε 2/ε 3 ε 2/ε 4 ε 3/ε 3 ε 3/ε 4 ε 4/ε 4 Total
  f N f N f N f N f N N       
AD 0.036 13 0.011 4 0.384 138 0.429 154 0.139 50 359 0.001 0.721 8.1*10-11 3.0*10-10 1.9*10-5 2.1*10-16
EOAD 0.029 5 0.006 1 0.390 67 0.372 64 0.203 35 172 0.004 0.653 1.1*10-7 2.9*10-5 5.8*10-8 2.5*10-13
LOAD 0.038 7 0.016 3 0.386 71 0.478 88 0.082 15 184 0.010 1.000 3.8*10-8 1.6*10-10 0.056 2.5*10-11
FH+ 0.029 5 0.000 0 0.341 59 0.468 81 0.162 28 173 0.004 0.146 2.8*10-10 9.8*10-10 1.4*10-5 4.1*10-16
FH- 0.039 7 0.022 4 0.425 77 0.392 71 0.122 22 181 0.010 0.727 3.3*10-6 3.5*10-6 0.001 6.1*10-9
Male 0.043 6 0.021 3 0.390 55 0.447 63 0.099 14 141 0.053 1.000 1.8*10-5 1.8*10-6 0.099 6.3*10-7
Female 0.032 7 0.005 1 0.381 83 0.417 91 0.165 36 218 0.015 0.559 1.7*10-6 6.4*10-5 8.7*10-5 8.9*10-10
EOAD vs. LOAD 0.772 0.624 1.000 0.053 0.001 0.009
Controls 0.106 26 0.016 4 0.654 161 0.187 46 0.037 9 246       
Male 0.113 13 0.017 2 0.661 76 0.165 19 0.043 5 115       
Female 0.099 13 0.015 2 0.649 85 0.206 27 0.031 4 131       
  1. f, N, AD, EOAD, LOAD, Controls and the comparing methods see Table 1. EOAD vs. LOAD, comparing EOAD and LOAD. α was set at 0.010 (or 0.002) for each genotype comparison between overall AD and controls (or between AD subgroups and controls), referring to Table 1. ε 2/ ε 3, the genotype consists of allele ε 2 and allele ε 3; as analogy.