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Table 2 Distributions of the genotype frequencies of the APOE gene variations in European-American subjects

From: Variation at APOE and STH loci and Alzheimer's disease

 

APOE genotypes

Exact P-values

 

ε 2/ε 3

ε 2/ε 4

ε 3/ε 3

ε 3/ε 4

ε 4/ε 4

Total

ε 2/ε 3

ε 2/ε 4

ε 3/ε 3

ε 3/ε 4

ε 4/ε 4

Total

 

f

N

f

N

f

N

f

N

f

N

N

      

AD

0.036

13

0.011

4

0.384

138

0.429

154

0.139

50

359

0.001

0.721

8.1*10-11

3.0*10-10

1.9*10-5

2.1*10-16

EOAD

0.029

5

0.006

1

0.390

67

0.372

64

0.203

35

172

0.004

0.653

1.1*10-7

2.9*10-5

5.8*10-8

2.5*10-13

LOAD

0.038

7

0.016

3

0.386

71

0.478

88

0.082

15

184

0.010

1.000

3.8*10-8

1.6*10-10

0.056

2.5*10-11

FH+

0.029

5

0.000

0

0.341

59

0.468

81

0.162

28

173

0.004

0.146

2.8*10-10

9.8*10-10

1.4*10-5

4.1*10-16

FH-

0.039

7

0.022

4

0.425

77

0.392

71

0.122

22

181

0.010

0.727

3.3*10-6

3.5*10-6

0.001

6.1*10-9

Male

0.043

6

0.021

3

0.390

55

0.447

63

0.099

14

141

0.053

1.000

1.8*10-5

1.8*10-6

0.099

6.3*10-7

Female

0.032

7

0.005

1

0.381

83

0.417

91

0.165

36

218

0.015

0.559

1.7*10-6

6.4*10-5

8.7*10-5

8.9*10-10

EOAD vs. LOAD

0.772

0.624

1.000

0.053

0.001

0.009

Controls

0.106

26

0.016

4

0.654

161

0.187

46

0.037

9

246

      

Male

0.113

13

0.017

2

0.661

76

0.165

19

0.043

5

115

      

Female

0.099

13

0.015

2

0.649

85

0.206

27

0.031

4

131

      
  1. f, N, AD, EOAD, LOAD, Controls and the comparing methods see Table 1. EOAD vs. LOAD, comparing EOAD and LOAD. α was set at 0.010 (or 0.002) for each genotype comparison between overall AD and controls (or between AD subgroups and controls), referring to Table 1. ε 2/ ε 3, the genotype consists of allele ε 2 and allele ε 3; as analogy.