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Table 4 Distributions of the frequencies of the genotypes with ascending APOE allele number

From: Variation at APOE and STH loci and Alzheimer's disease

  Number of ε 2 alleles Chi-Square test for trend Number of ε 3 alleles Chi-Square test for trend Number of ε 4 alleles Chi-Square test for trend
  0 1 2 χ 2 P 0 1 2 χ 2 P 0 1 2 χ 2 P
  f N f N f N    f N f N f N    f N f N f N   
AD 0.953 342 0.047 17 0 0 11.32 0.001 0.150 54 0.465 167 0.384 138 43.02 < 0.0001 0.421 151 0.440 158 0.139 50   < 0.0001
EOAD 0.965 166 0.035 6 0 0 9.73 0.002 0.209 36 0.401 69 0.390 67 37.41 < 0.0001 0.419 72 0.378 65 0.203 35 56.72 < 0.0001
LOAD 0.946 174 0.054 10 0 0 5.69 0.017 0.098 18 0.516 95 0.386 71 26.27 < 0.0001 0.424 78 0.494 91 0.082 15 42.63 < 0.0001
FH+ 0.971 168 0.029 5 0 0 11.46 0.001 0.162 28 0.497 86 0.341 59 41.06 < 0.0001 0.370 64 0.468 81 0.162 28 61.13 < 0.0001
FH- 0.939 170 0.061 11 0 0 4.49 0.034 0.144 26 0.431 78 0.425 77 24.67 < 0.0001 0.464 84 0.414 75 0.122 22 38.60 < 0.0001
Male 0.936 132 0.064 9 0 0 3.29 0.069 0.121 17 0.489 69 0.390 55 16.00 < 0.0001 0.433 61 0.468 66 0.099 14 24.98 < 0.0001
Female 0.963 210 0.037 8 0 0 8.02 0.005 0.170 37 0.450 98 0.381 83 26.33 < 0.0001 0.413 90 0.422 92 0.165 36 38.04 < 0.0001
Controls 0.878 216 0.122 30 0 0    0.053 13 0.293 72 0.654 161    0.760 187 0.203 50 0.037 9   
Male 0.870 100 0.130 15 0 0    0.061 7 0.278 32 0.661 76    0.774 89 0.183 21 0.043 5   
Female 0.885 116 0.115 15 0 0    0.046 6 0.305 40 0.649 85    0.748 98 0.221 29 0.031 4   
  1. f, N, AD, EOAD, LOAD, Controls, and the comparing methods see Tables 1 and 2.
  2. α was set at 0.017 (or 0.003) for each Chi-Square test for trend analysis in overall AD (or AD subgroups), referring to Tables 1 and 2.