Figure 1
From: Influence of methylphenidate on brain development – an update of recent animal experiments
Neuronal connections of Prefrontal Cortex. Dopamine (DA) fibres arising in the ventral tegmental area terminate on GABAergic interneurons and glutamatergic pyramidal cells in the PFC. DA serves as a switch between cortical (with low DA transmission) and thalamic input (with high DA transmission) [117,118]. +-signs signify an excitation and – signs signify an inhibition. IV, V and VI = layer IV, V and VI; P = pyramidal cell; PFC = prefrontal cortex; TH = thalamus; UC = u-shaped cortical connections; VTA = ventral tegmental area.