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Table 4 Multi-marker haplotype analyses

From: The μ-opioid receptor gene and smoking initiation and nicotine dependence

Marker Combination Global P Value* Risk Haplotype Case Count Case Frequency Control Count Control Frequency Odds Ratio χ2 Risk Haplotype P Value
Smoking Initiation
5-6-7 0.0022 1-2-1 321.9 0.363 149.6 0.307 1.3 4.34 0.0373
   1-2-2 11.4 0.013 0.0 0.000 9.30 0.0023
5-6-7-8 0.0031 1-2-1-2 318.2 0.358 146.6 0.301 1.3 4.74 0.0294
   1-2-2-2 11.7 0.013 0.0 0.000 9.66 0.0019
1-3-5-6-7 0.0035 1-1-1-2-1 282.2 0.318 124.7 0.256 1.6 4.22 0.0400
   1-1-1-2-2 10.16 0.011 0.0 0.000 8.37 0.0038
Nicotine Dependence
5-6-7 0.0514 1-2-2 9.9 0.022 1.2 0.003 8.3 6.61 0.0102
5-6-7-8 0.0630 1-2-2-2 10.0 0.026 1.0 0.003 8.8 7.09 0.0077
  1. * The empirical p values obtained from 10,000 permutations for combinations 5-6-7, 5-6-7-8 and 1-3-5-6-7 for SI were 0.0090, 0.0114 and 0.0259 respectively.