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Table 3 Effects of haloperidol on the mC content of leukocyte, brain, and liver DNA

From: Haloperidol treatment induces tissue- and sex-specific changes in DNA methylation: a control study using rats

  

mC content (mean ± SD)

Sex

Treatmenta

Leukocytes

P

Brain

P

Liver

P

Male

Haloperidol

3.817 ± 0.036

0.212

3.632 ± 0.047

0.273

3.445 ± 0.027

0.013

 

Placebob

3.843 ± 0.042

 

3.650 ± 0.023

 

3.412 ± 0.033

 

Female

Haloperidol

3.812 ± 0.050

0.064

3.615 ± 0.031

0.026

3.449 ± 0.055

0.089

 

Placebob

3.771 ± 0.048

 

3.652 ± 0.031

 

3.426 ± 0.027

 
  1. aEach treatment-group consisted of 10 rats.
  2. binjected with solvent, NaOH-buffered acetic acid (pH6.0), alone.
  3. Differences in mean mC content between haloperidol- and placebo-treated groups were evaluated with the Mann-Whitney U test.