Skip to main content

Table 3 Effects of haloperidol on the mC content of leukocyte, brain, and liver DNA

From: Haloperidol treatment induces tissue- and sex-specific changes in DNA methylation: a control study using rats

   mC content (mean ± SD)
Sex Treatmenta Leukocytes P Brain P Liver P
Male Haloperidol 3.817 ± 0.036 0.212 3.632 ± 0.047 0.273 3.445 ± 0.027 0.013
  Placebob 3.843 ± 0.042   3.650 ± 0.023   3.412 ± 0.033  
Female Haloperidol 3.812 ± 0.050 0.064 3.615 ± 0.031 0.026 3.449 ± 0.055 0.089
  Placebob 3.771 ± 0.048   3.652 ± 0.031   3.426 ± 0.027  
  1. aEach treatment-group consisted of 10 rats.
  2. binjected with solvent, NaOH-buffered acetic acid (pH6.0), alone.
  3. Differences in mean mC content between haloperidol- and placebo-treated groups were evaluated with the Mann-Whitney U test.