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Table 1 Genotype and allelic distributions of the VMAT1 SNPs in patients with schizophrenia and controls

From: Association study of the vesicular monoamine transporter 1 (VMAT1) gene with schizophrenia in a Japanese population

dbSNP ID Positiona Inter-SNP distance (bp) Group N Genotype frequency (GF) Allele frequency (AF) Odds ratio (95% CI) Chi-square test
            HWE
(df = 1)
GF
(df = 2)
AF
(df = 1)
  7883394     C/C A/C A/A C A     
SNP1 rs2270641 Exon 2 ____ Patients 351 45 (0.13) 153 (0.44) 153 (0.44) 243 (0.35) 459 (0.65) 0.83 – 1.29 χ2 = 0.48, P = 0.49 P = 0.95 P = 0.75
  Pro4Thr   Controls 360 49 (0.14) 157 (0.44) 154 (0.43) 255 (0.35) 465 (0.65) 1.04 χ2 = 0.78, P = 0.37 χ2 = 0.11 χ2 = 0.10
  7881755     C/C G/C G/G C G     
SNP2 rs2270637 Exon 3 1639 Patients 352 11 (0.03) 130 (0.37) 211 (0.60) 152 (0.22) 552 (0.78) 1.09 – 1.77 χ2 = 2.9, P = 0.09 P = 0.01 P = 0.01
  Thr98Ser   Controls 362 28 (0.08) 144 (0.40) 190 (0.52) 200 (0.28) 524 (0.72) 1.39 χ2 = 0.0, P = 0.92 χ2 = 9.09 χ2 = 7.00
  7881641     C/C T/C T/T C T     
SNP3 rs1390938 Exon 3 114 Patients 352 188 (0.53) 135 (0.38) 29 (0.08) 511 (0.73) 193 (0.27) 0.70 – 1.13 χ2 = 0.46, P = 0.50 P = 0.44 P = 0.33
  Thr136Ile   Controls 360 200 (0.56) 139 (0.39) 21 (0.06) 539 (0.75) 181 (0.25) 0.89 χ2 = 0.24, P = 0.62 χ2 = 1.62 χ2 = 0.95
  7850482     G/G G/C C/C G C     
SNP4 rs17092104 Exon 13 31159 Patients 352 0 (0.00) 23 (0.07) 329 (0.93) 23 (0.03) 681 (0.97) 0.38 – 1.34 χ2 = 0.40, P = 0.53 P = 0.28 P = 0.29
  Val392Leu   Controls 363 0 (0.00) 17 (0.05) 346 (0.95) 17 (0.02) 709 (0.98) 0.71 χ2 = 0.21, P = 0.65 χ2 = 1.16 χ2 = 1.13
  1. aChromosome position was according to the dbSNP database.
  2. HWE: Hardy-Weinberg equilibrium
  3. P values of < 0.05 are underlined.