Table 1 Genotype and allelic distributions of the VMAT1 SNPs in patients with schizophrenia and controls
dbSNP ID | Positiona | Inter-SNP distance (bp) | Group | N | Genotype frequency (GF) | Allele frequency (AF) | Odds ratio (95% CI) | Chi-square test | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HWE (df = 1) | GF (df = 2) | AF (df = 1) | |||||||||||
7883394 | C/C | A/C | A/A | C | A | ||||||||
SNP1 rs2270641 | Exon 2 | ____ | Patients | 351 | 45 (0.13) | 153 (0.44) | 153 (0.44) | 243 (0.35) | 459 (0.65) | 0.83 – 1.29 | χ2 = 0.48, P = 0.49 | P = 0.95 | P = 0.75 |
Pro4Thr | Controls | 360 | 49 (0.14) | 157 (0.44) | 154 (0.43) | 255 (0.35) | 465 (0.65) | 1.04 | χ2 = 0.78, P = 0.37 | χ2 = 0.11 | χ2 = 0.10 | ||
7881755 | C/C | G/C | G/G | C | G | ||||||||
SNP2 rs2270637 | Exon 3 | 1639 | Patients | 352 | 11 (0.03) | 130 (0.37) | 211 (0.60) | 152 (0.22) | 552 (0.78) | 1.09 – 1.77 | χ2 = 2.9, P = 0.09 | P = 0.01 | P = 0.01 |
Thr98Ser | Controls | 362 | 28 (0.08) | 144 (0.40) | 190 (0.52) | 200 (0.28) | 524 (0.72) | 1.39 | χ2 = 0.0, P = 0.92 | χ2 = 9.09 | χ2 = 7.00 | ||
7881641 | C/C | T/C | T/T | C | T | ||||||||
SNP3 rs1390938 | Exon 3 | 114 | Patients | 352 | 188 (0.53) | 135 (0.38) | 29 (0.08) | 511 (0.73) | 193 (0.27) | 0.70 – 1.13 | χ2 = 0.46, P = 0.50 | P = 0.44 | P = 0.33 |
Thr136Ile | Controls | 360 | 200 (0.56) | 139 (0.39) | 21 (0.06) | 539 (0.75) | 181 (0.25) | 0.89 | χ2 = 0.24, P = 0.62 | χ2 = 1.62 | χ2 = 0.95 | ||
7850482 | G/G | G/C | C/C | G | C | ||||||||
SNP4 rs17092104 | Exon 13 | 31159 | Patients | 352 | 0 (0.00) | 23 (0.07) | 329 (0.93) | 23 (0.03) | 681 (0.97) | 0.38 – 1.34 | χ2 = 0.40, P = 0.53 | P = 0.28 | P = 0.29 |
Val392Leu | Controls | 363 | 0 (0.00) | 17 (0.05) | 346 (0.95) | 17 (0.02) | 709 (0.98) | 0.71 | χ2 = 0.21, P = 0.65 | χ2 = 1.16 | χ2 = 1.13 | ||