Selection for tameness modulates the expression of heme related genes in silver foxes

Table 3 Contrasts comparing the average gene expression levels in brain between groups of foxes.

Contrast	Gene	Fold Change	p-value
1) S vs NS^a	HBE*	-3.1	0.005
	HBB	-2.3	0.002
	HBA	-2.2	0.048
	HEBP1*	-1.5	0.022
2) Cross vs parental^b	HBE	-1.2	0.623
	HBB	1.4	0.132
	HBA	1.2	0.617
	HEBP1	-1.1	0.365
3) Wild vs Farm	HBE*	2.7	0.008
	HBB	1.0	0.853
	HBA	-1.9	0.059
	HEBP1*	-1.3	0.143

a = test of composite additive genetic effect.
b = test for composite genetic dominance effect.
* = previously reported in Lindberg et al [11].
The three contrasts tests the following mRNA differences: 1) difference between selected and non-selected farm foxes, 2) difference between off-spring from crossing and back crossing S and NS with the weighted average of the parental S and NS lines, and 3) difference between the average of farmed foxes (S, NS and Cross) and wild red foxes.

ISSN: 1744-9081