Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study

Table 3 Relation of gene polymorphisms with short-term and long-term smoking cessation among 593 women, Seattle, WA, 1993–1998.

	Short-term smoking cessation						Long-term smoking cessation
	Quit		Did not quit				Quit		Did not quit
Polymorphism	N	%	N	%	RR	95% CI	N	%	N	%	RR	95% CI
COMT Val158Met
Val/Val	25	22	112	25	1.0	Ref	24	26	120	24	1.0	Ref
Val/Met	63	56	204	46	1.3	0.9, 2.0	49	53	234	48	1.0	0.7, 1.6
Met/Met	25	22	124	28	0.9	0.6, 1.5	19	21	136	28	0.7	0.4, 1.3
DRD2 Taq1A
A2/A2	77	67	283	64	1.0	Ref	62	67	316	64	1.0	Ref
A2/A1; A1/A1	38	33	160	36	0.9	0.6, 1.3	31	33	177	36	0.9	0.6, 1.4
DRD2 -141C Ins/Del
Ins/Ins	91	79	337	76	1.0	Ref	75	80	378	76	1.0
Ins/Del; Del/Del	24	21	106	24	0.9	0.6, 1.3	18	20	117	24	0.8	0.5, 1.3
DRD3 Ser9Gly
Ser/Ser	53	46	188	42	1.0	Ref	45	48	211	43	1.0	Ref
Ser/Gly; Gly/Gly	62	54	256	58	0.9	0.5, 1.2	48	52	284	57	0.8	0.6, 1.2
DRD4 VNTR
Short/Short	71	63	256	59	1.0	Ref	53	58	290	60	1.0	Ref
Short/Long; Long/Long	42	37	179	41	0.9	0.6, 1.2	39	42	193	40	1.1	0.7, 1.6
SLC6A3 VNTR
No 9 repeats	57	51	259	59	1.0	Ref	50	55	283	58	1.0
One or two 9 repeats	55	49	183	41	1.3	0.9, 1.8	41	44	209	42	1.1	0.7, 1.6
TH VNTR
No 10 repeats	50	43	207	46	1.0	Ref	39	42	235	47	1.0	Ref
One or two 10 repeats	66	57	240	54	1.1	0.8, 1.5	54	59	265	53	1.2	0.8, 1.7

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