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Table 3 Allele and genotype frequencies of dopamine receptor polymorphisms in patient and control groups.

From: Association of dopamine receptor polymorphisms with schizophrenia and antipsychotic response in a South Indian population

Locus Genotype Frequency χ2 P Allele Frequency χ2 P
Taq1B (rs 1079597) B1B1 B1B2 B2B2 2.0 0.36 B1 B2 0.03 0.86
Cases (n = 212) 0.05(11) 0.41(86) 0.54(115)    0.25(108) 0.75(316)   
Controls (n = 196) 0.08(16) 0.36(70) 0.56(110)    0.26(102) 0.74(290)   
Taq1D (rs 1800498) D1D1 D1D2 D2D2 2.49 0.29 D1 D2 0.004 0.95
Cases (n = 211) 0.12(25) 0.58(123) 0.30(63)    0.41(173) 0.59(249)   
Controls (n = 195) 0.15(30) 0.51(99) 0.34(66)    0.41(159) 0.59(231)   
S311C (rs 1801028) GG GC CC 0.41 0.81 G C 0.01 0.92
Cases (n = 210) 0.80(169) 0.18(38) 0.10(3)    0.89(376) 0.11(44)   
Controls (n = 195) 0.81(159) 0.16(32) 0.02(4)    0.90(350) 0.10(40)   
H313H 1 (rs 6275) TT TC CC 9.60 0.008* T C 2.92 0.09
Cases (n = 213) 0.36(76) 0.43(92) 0.21(45)    0.57(244) 0.43(182)   
Controls (n = 193) 0.23(44) 0.57(110) 0.20(39)    0.51(198) 0.49(188)   
Taq1A 2 (rs 1800497) A1A1 A1A2 A2A2 4.88 0.09 A1 A2 0.57 0.45
Cases (n = 212) 0.08(17) 0.44(93) 0.48(102)    0.30(127) 0.70(297)   
Controls (n = 194) 0.15(29) 0.40(77) 0.45(88)    0.35(135) 0.65(253)   
  1. 1H313H dominant model (TT Vs TC+CC) P = 0.0045, Odds = 1.879, CI = 1.212 to 2.911
  2. 2 Taq1A recessive model (A1A1 Vs A1A2+A2A2) P = 0.029, Odds = 0.4960, CI = 0.2632 to 0.9348
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