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Table 5 Allele and genotype frequencies of dopamine receptor polymorphism in responder and non responder groups in patient population based on percent response score ≤ 50% ≥.

From: Association of dopamine receptor polymorphisms with schizophrenia and antipsychotic response in a South Indian population

Locus Genotype Frequency χ2 P Allele Frequency χ2 P
Taq1B (rs 1079597) B1B1 B1B2 B2B2 0.18 0.915 B1 B2 0.15 0.7
Responders(n = 121) 0.04(5) 0.42(51) 0.54(65)    0.25(61) 0.751(181)   
Nonresponders(n = 59) 0.05(3) 0.44(26) 0.51(30)    0.27(32) 0.73(86)   
Taq1D 1 (rs 1800498) D1D1 D1D2 D2D2 6.14 0.046* D1 D2 0.65 0.42
Responders (n = 121) 0.15(18) 0.54(65) 0.31(38)    0.42(101) 0.58(141)   
Nonresponders(n = 59) 0.03(2) 0.68(40) 0.29(17)    0.37(44) 0.63(74)   
S311C (rs 1801028) GG GC CC 0.99 0.61 G C 0.26 0.61
Responders (n = 120) 0.79(95) 0.19(23) 0.02(2)    0.89(213) 0.11(27)   
Nonresponders(n = 58) 0.81(47) 0.19(11) (0)    0.90 (105) 0.10(11)   
H313H 2 (rs 6275) TT TC CC 5.57 0.06 T C 1.76 0.18
Responders (n = 122) 0.36(44) 0.41(50) 0.23(28)    0.57(138) 0.43(106)   
Nonresponders(n = 59) 0.20(12) 0.58(34) 0.22(13)    0.49(58) 0.51(60)   
Taq1A (rs 1800497) A1A1 A1A2 A2A2 1.91 0.39 A1 A2 1.44 0.23
Responders (n = 121) 0.09(10) 0.42(51) 0.49(60)    0.29(71) 0.71(171)   
Nonresponders(n = 59) 0.08(5) 0.53(31) 0.39(23)    0.35(41) 0.65(74)   
  1. 1Taq1D recessive model (D1D1vs D1D2 +D2D2) P= 0.023, Odds = 4.98, CI = 1.115 to 22.25
  2. 2H313H dominant model (TT Vs TC+CC) P= 0.0490, Odds = 0.490, CI = 0.2394 to 1.004
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