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Table 5 Allele and genotype frequencies of dopamine receptor polymorphism in responder and non responder groups in patient population based on percent response score ≤ 50% ≥.

From: Association of dopamine receptor polymorphisms with schizophrenia and antipsychotic response in a South Indian population

Locus

Genotype Frequency

χ2

P

Allele Frequency

χ2

P

Taq1B (rs 1079597)

B1B1

B1B2

B2B2

0.18

0.915

B1

B2

0.15

0.7

Responders(n = 121)

0.04(5)

0.42(51)

0.54(65)

  

0.25(61)

0.751(181)

  

Nonresponders(n = 59)

0.05(3)

0.44(26)

0.51(30)

  

0.27(32)

0.73(86)

  

Taq1D 1 (rs 1800498)

D1D1

D1D2

D2D2

6.14

0.046*

D1

D2

0.65

0.42

Responders (n = 121)

0.15(18)

0.54(65)

0.31(38)

  

0.42(101)

0.58(141)

  

Nonresponders(n = 59)

0.03(2)

0.68(40)

0.29(17)

  

0.37(44)

0.63(74)

  

S311C (rs 1801028)

GG

GC

CC

0.99

0.61

G

C

0.26

0.61

Responders (n = 120)

0.79(95)

0.19(23)

0.02(2)

  

0.89(213)

0.11(27)

  

Nonresponders(n = 58)

0.81(47)

0.19(11)

(0)

  

0.90 (105)

0.10(11)

  

H313H 2 (rs 6275)

TT

TC

CC

5.57

0.06

T

C

1.76

0.18

Responders (n = 122)

0.36(44)

0.41(50)

0.23(28)

  

0.57(138)

0.43(106)

  

Nonresponders(n = 59)

0.20(12)

0.58(34)

0.22(13)

  

0.49(58)

0.51(60)

  

Taq1A (rs 1800497)

A1A1

A1A2

A2A2

1.91

0.39

A1

A2

1.44

0.23

Responders (n = 121)

0.09(10)

0.42(51)

0.49(60)

  

0.29(71)

0.71(171)

  

Nonresponders(n = 59)

0.08(5)

0.53(31)

0.39(23)

  

0.35(41)

0.65(74)

  
  1. 1Taq1D recessive model (D1D1vs D1D2 +D2D2) P= 0.023, Odds = 4.98, CI = 1.115 to 22.25
  2. 2H313H dominant model (TT Vs TC+CC) P= 0.0490, Odds = 0.490, CI = 0.2394 to 1.004