Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia

Table 1 Genotype and allele frequencies and tests of association with schizophrenia on chromosome 6p22.3 at the DTNBP1 locus in cases and controls

Marker	Distance to next marker (bp)	Genotypes and frequencies			Allelic bases and frequencies		χ²	Significance (p =)
rs2619539 P1655	0	CC	GC	GG	C	G	0.0194	0.8891
Controls		68	135	64	271	263
Schizophrenia		68	124	62	260	248
rs3213207 P1635	7247	AA	AG	GG	A	G	0.248	0.6182
Controls		345	85	5	775	95
Schizophrenia		305	71	3	682	78
rs1011313 P1325	5330	CC	CT	TT	C	T	1.036	0.3088
Controls		356	70	6	782	82
Schizophrenia		329	79	6	737	91
rs2005976 P1757	17370	AA	GA	GG	A	G	0.949	0.3301
Controls		17	135	279	169	693
Schizophrenia		8	119	254	135	627
rs760761 P1320	330	CC	CT	TT	C	T	0.274	0.6006
Controls		274	135	17	683	169
Schizophrenia		247	115	13	609	141
rs2619522 P1763	2517	GG	TG	TT	G	T	0.427	0.5135
Controls		17	134	283	168	700
Schizophrenia		11	128	275	150	678
rs2619536	10198	CC	CT	TT	C	T	0.184	0.6678
Controls		5	80	344	90	768
Schizophrenia		2	67	292	71	651
rs2619538 SNPA	1362	TT	TA	AA	T	A	0.038	0.8462
Controls		134	208	88	476	384
Schizophrenia		136	200	94	472	388

ISSN: 1744-9081