Behavioral responses of the F344 and WKY in the EPM, basally and immediately after 1 hr restraint stress. Groups are as described in Figure 1. (A) time spent (seconds) in open arms; (B) number of entries into open arms; (C) time spent (seconds) in center; (D) total number of entries (closed + open arm entries); (E) number of rears; (F) time spent (seconds) grooming. Values are means +/- SEM. Asterisks indicate significant effect of strain; pound signs indicate significant effect of repeated testing; plus signs indicate significant effect of stress. All significant values are p < 0.05 by Bonferroni post hoc test.