Table 1 Summary of main findings related to disease mechanisms in Chronic Fatigue Syndrome
From: Can sustained arousal explain the Chronic Fatigue Syndrome?
Predisposing factors |
|---|
   Genetic traits |
Polymorphisms in autonomic and endocrine effector systems |
   Personality traits |
Inappropriate illness perceptions |
Precipitating factors |
   Long-lasting infections |
   Critical life events |
   Perceived chronic difficulties |
Perpetuating and associated factors |
   Hemodynamic alterations |
Sympathetic vs parasympathetic predominance |
   Immune alterations |
Th2 vs Th1 predominance |
   Endocrine alterations |
Attenuated HPA axis |
   Skeletal muscle alterations |
Attenuated cortical activation |
Increased oxidative stress |
   Cognitive alterations |
Impaired memory and information processing |