Combined ethanol exposures leads to behavioral alterations in adulthood as compared with adolescent exposure alone. Mean composite reflexive sniffing index values (± sem) for all female observer animals that received adolescent ethanol exposure as a function of prenatal treatment. Female animals display a differential effect of prenatal treatment on the response to ethanol odor in adulthood. ET/ET = ethanol animals with ethanol exposure in adolescence. Control/ET = pair-fed and free choice animals with ethanol exposure in adolescence.