Skip to main content

Table 2 Cross sectional neuroimaging studies implicating the amygdala in Autism Spectrum Disorders

From: Conceptual and methodological challenges for neuroimaging studies of autistic spectrum disorders

  Study ASDs Group
N Age (M ± SD)
Ctr Group
N Age (M ± SD)
Results  
Anatomical Studies Howard MA et al., 2000[56] 10 (15.8-40.3)a 10 (age matched) Increased  
  Sparks BF et al., 2002[7] 45 (47.4 ± 4.2)b 26 (47.5 ± 6.2)b
14c (47.5 ± 5.6)b
Increased  
  Aylward EH et al., 1999[47] 14 (20.5 ± 1.8) 14 (20.3 ± 1.7) Decreased  
  Pierce K. et al., 2001[57] 7 (21-41)a 8 (20-42)a Decreased  
  Haznedar MM et al., 2000[58] 17 (27.7 ± 11.3) 17 (28.8 ± 9.4) Normal  
  Schumann CM 2004[17] 71 (7.5 - 18.5)a 27 (7.5-18.5)a Amygdala initially increased but does not undergo the age-related increase
  Nacewicz BM et al., 2006 [55] 16 (14.3 ± 4.7) 14 (13.7 ± 3.9) Decreased  
  Munson J. et al., 2006 [54] 45 (47.4 ± 4.2)b - Increase in right amygdala  
  Schumann CM et al., 2009 [80] 50 (22-61)b 39 (20-51)b Increased  
     Results Task Design
Functional Studies Baron Cohen S. et al., 1999[81] 6 (26.3 ± 2.1) 12 (25.5 ± 2.8) Lack to AMY activity when making mentalistic inferences from the eyes Interfering mental status from the eyes region
  Critchley HD et al., 2000[82] 9 (37 ± 7) 9 (27 ± 7) Failed to activate left AMY in the implicity task Explicitly and implicitly processing emotional facial
  Wang AT et al., 2004[42] 12 (12.2 ± 4.8) 12 (11.8 ± 2.5) AMY activity moderated by task demands in control but not in ASD Face labelling vs matching emotional expression
  Ashwin C. et al., 2007[69] 13 (31.2 ± 9.1) 13 (25.6 ± 5.1) Controls showed greater activation in the left AMY Fearful face-processing
  Kleinhans NM et al., 2009[83] 19 (21.9 ± 5.9) 20 (24.7 ± 7.9) AMY hyperarousal Upright neutral faces, inverted neutral faces
  Corbett BA et al., 2009[79] 12 (8-12)a 15 (8-12)a Diminished activation of the AMY in emotion matching Matching facial expressions and people
  1. aage range
  2. bmonths
  3. cidiopathic developmental delays (DD)
  4. AMY = amygdala
\