Gene × environment interactions for ADHD: synergistic effect of 5HTTLPR genotype and youth appraisals of inter-parental conflict

Table 3 ADHD and externalizing symptoms: main effect tests of high, intermediate and low activity 5HTTLPR genotypes.

	High	Intermediate	Low	p	p^e	p^eas
N	78	137	89
KSAD Diagnostics
Inattentive Symptoms	5.5 (3.5)	6.0 (3.2)	5.5 (3.7)	.49	.51	.22
Hyperactive Symptoms	3.7 (3.3)	3.8 (3.3)	4.2 (3.3)	.60	.47	.52
ODD Symptoms	1.7 (2.3)	1.6 (2.2)	1.8 (2.4)	.81	.80	.83
CD Symptoms	.33 (.65)	.57 (1.3)	.30 (.87)	.10	.09	.09
Conners' Teacher Report
Cognitive Problems	3.0 (3.5)	3.4 (4.0)	3.8 (4.7)	.47	.45	.44
Hyperactivity	4.3 (4.8)	3.6 (3.8)	3.1 (3.8)	.20	.24	.13
ADHD Rating Scale Teacher Report
Inattention	4.6 (6.7)	4.3 (6.1)	4.9 (6.5)	.95	.96	.93
Hyperactivity	3.1 (5.9)	2.4 (4.5)	2.3 (4.6)	.49	.65	.46

Note. High activity genotypes (La/La); Intermediate activity genotypes (La/Lg, La/short); Low activity genotypes (Lg/Lg, Lg/short, short/short.) p^e = ethnicity corrected p value, p^eas = ethnicity age, and sex corrected p value. Inattentive, Hyperactive, ODD, and CD symptoms are parent report on the KSADS-E. Conners' Scores and ADHD Rating Scale scores are raw total scores on each measure (higher scores signify symptoms/problems).

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