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Table 2 Four-SNP haplotype frequencies and results of the association analysis between patients and controls.

From: Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study

Haplotype

Frequency

Case, control ratios

χ2

P-value

A-A-A-G

0.206

0.217, 0.194

0.26

0.610

C-A-C-G 1

0.177

0.121, 0.241

7.79

0.005

A-G-A-G

0.177

0.146, 0.212

2.36

0.124

A-G-A-T

0.139

0.114, 0.167

1.81

0.178

C-A-A-G

0.126

0.138, 0.112

0.49

0.484

A-A-A-T 1

0.094

0.147, 0.035

11.46

0.0007

A-A-C-T

0.020

0.033, 0.005

3.12

0.077

A-G-C-G

0.019

0.017, 0.022

0.10

0.752

A-A-C-G

0.017

0.024, 0.008

1.25

0.263

C-G-A-T

0.012

0.022, 0.002

2.52

0.112

  1. SNP, single nucleotide polymorphism.
  2. Case refers to patients with schizophrenia, and control refers to control subjects.
  3. Haplotypes listed are only those with a frequency ≥1%.
  4. The P-values given are based on 10000 permutations using the Haploview program.
  5. Associations reaching nominal significance (P < 0.05) are shown in bold.
  6. 1Note that C-A-C-G haplotype is an allelic opposite at all, but the second, loci of A-A-A-T haplotype. C-G-C-G haplotype that is the exact allelic opposite of A-A-A-T haplotype was absent in our patient and control populations.