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Table 3 SPM analyses performed in the subgroup of 19 women after the exclusion of the homozygote carriers of the S allele of the 5-HTTLPR polymorphism.

From: 5-HT1A gene promoter polymorphism and [18F]MPPF binding potential in healthy subjects: a PET study

  19 women
contrast Anatomic brain regions covered MNI coordinates (x, y, z (mm)) Z score, k, p
GG-CC bulbar serotoninergic nuclei 0; -22; -46 Z = 4.75, k = 244, p = 0.021*
  left superior and middle frontal gyri (F1 and F2) -16; 18; 50 Z = 4.73, k = 480, p = 0.001*
  right mesial frontal and left supplementary motor area 2; -14; 58 Z = 4.55, k = 885, p < 0.001*
  left and right mesial frontal pole -2; 60; -2 Z = 4.52, k = 646, p < 0.001*
  left lateral middle temporal cortex (T2) -58; -14; -26 Z = 4.20, k = 198, p = 0.048*
  right anterior mesial frontal 12; 36; 38 Z = 4.12, k = 247, p = 0.020*
  left anterior inferior frontal gyrus (F3) -46; 42; 6 Z = 3.66, k = 298, p = 0.009*
GG-CG right and left mesial frontal pole 4; 62; 10 Z = 5.14, k = 3248, p < 0.001*
  right lateral orbitofrontal cortex 26; -38; -20 Z = 4.95, k = 357, p = 0.003*
  right parahippocampal gyrus 38; -16; -26 Z = 4.87, k = 273, p = 0.013*
  right temporal pole 30; 14; -38 Z = 4.75, k = 574, p < 0.001*
  right lateral second and third temporal cortex (T2, T3) 60; -22; -16 Z = 4.53, k = 545, p < 0.001*
  left lateral second and third temporal cortex (T2, T3) -60; -12; -24 Z = 4.45, k = 383, p = 0.002*
  left temporal pole -34; 10; -40 Z = 4.16, k = 393, p = 0.002*
  right anterior superior and middle frontal gyri (F1, F2) -14; 26; 52 Z = 4.05, k = 214, p = 0.036*
  right frontal operculum 52; 14; 6 Z = 3.97, k = 294, p = 0.009*
  left anterior inferior frontal gyrus (F3) -42; 28; -2 Z = 3.96, k = 501, p < 0.001*
  right dorsolateral frontal cortex 42; 36; 30 Z = 3.83, k = 373, p = 0.003*
CC-GG NS
CC-CG NS
CG-CC NS
CG-GG NS
GG - (GC+CC) left and right mesial frontal pole -2; 60; -2 Z = 4.92, k = 2877, p < 0.001*
  right lateral orbitofrontal cortex 26; -38; -20  
  right temporal pole 30; 14; -38 Z = 4.56, k = 215, p = 0.035*
  left superior and middle frontal gyri (F1, F2) -16; 20; 50 Z = 4.49, k = 411, p = 0.002*
  right lateral second and third temporal cortex (T2, T3) 60; -22; -16 Z = 4.43, k = 342, p = 0.004*
  left lateral middle temporal cortex (T2) -58; -12; -24 Z = 4.37, k = 321, p = 0.006*
  left superior frontal gyrus (F1) -42; 0; 42 Z = 4.22, k = 212, p = 0.037*
  right frontal operculum 54; 12; 6 Z = 3.88, k = 234, p = 0.025*
  left anterior inferior frontal gyrus (F3) -42; 28; -2 Z = 3.87, k = 469, p = 0.001*
  right dorsolateral frontal cortex 44; 38; 26 Z = 3.82, k = 368, p = 0.003*
(GC+CC) - GG NS
  1. k is the cluster size expressed in voxels. Only significant findings are shown. NS: no significant.