Association between polymorphisms of arachidonate 12-lipoxygenase (ALOX12) and schizophrenia in a Korean population

Table 1 Genotype distribution of SNPs of the ALOX12 gene among schizophrenia patients in a Korean population.

SNP	Amino acid	Genotype	Control N = 306		Schizophrenia N = 289		Model	OR	95% CI		p
			Freq.	%	Freq.	%			LCL	UCL
rs1126667	R261Q	G/G	96	31.4	77	26.6	Codominant	1.09	0.75	1.59	0.048
(Exon 6)		A/G	151	49.4	132	45.7	Dominant	1.26	0.88	1.80	0.200
		A/A	59	19.3	80	27.7	Recessive	1.60	1.09	2.35	0.015*
rs434473	S322N	A/A	96	31.4	78	27.0	Codominant	1.09	0.74	1.58	0.073
(Exon 8)		A/G	153	50.0	135	46.7	Dominant	1.24	0.87	1.76	0.240
		G/G	57	18.6	76	26.3	Recessive	1.56	1.06	2.30	0.025*
rs1042357	T364T	C/C	95	31.1	77	26.6	Codominant	1.07	0.73	1.57	0.050*
(Exon 8)	A/C	152	49.7		132	45.7	Dominant	1.24	0.87	1.77	0.240
		A/A	59	19.3	80	27.7	Recessive	1.60	1.09	2.35	0.015*

ALOX12, arachidonate 12-lipoxygenase; R, arginine; Q, glutamine; S, serine; N, asparagine; T, threonine; Freq, frequency; OR, odds ratio; CI, confidence interval; LCL, lower confidence limit; UCL, upper confidence limit; p, probability value.
*These values are not significant after the Bonferroni correction (number of tests = 18).

ISSN: 1744-9081