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Table 4 Results from univariate logistic regression analysis i.e., OR, 95% CI, Wald statistic, and probability values for predictor variables of MDD suicide behaviors

From: Effect of Tryptophan Hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression

Variables OR 95% CI Wald P value
Education under middle school 2.39 1.62-3.52 19.705 0.000
Married 0.20 0.12-0.32 46.600 0.000
Age of onset (= ≥ 35 years) 0.79 0.54-1.17 1.407 0.236
Short course of diseases (= ≤ 1 year) 0.83 0.57-1.21 0.943 0.332
Employed 0.67 0.45-1.00 3.809 0.051
Family history of Mental illness 0.94 0.64-1.39 0.086 0.769
Onset abruptly or subacute 1.13 0.76-1.68 0.366 0.545
Predisposing factors 1.15 0.78-1.72 0.500 0.479
Unhappy childhood 1.12 0.70-1.80 0.233 0.650
Family history of suicide 2.58 1.47-4.54 11.328 0.001
Physical disease 1.15 0.69-1.93 0.279 0.597
Monthly income (= < $40) 2.02 1.37-2.99 7.892 0.005
Smoking 1.64 1.02-2.65 4.164 0.041
Drinking 1.64 1.07-2.53 5.178 0.023
Introversion 1.90 1.25-2.87 9.155 0.002
Economic pressure 2.58 1.64-4.05 17.434 0.000
Unhappy a month ago 0.96 0.65-1.42 0.040 0.841
Unhappy a year ago 1.14 0.76-1.72 0.397 0.529
Unhappy after a year 0.87 0.60-1.31 0.362 0.547
Friend suicide two weeks ago 1.11 0.46-2.66 0.050 0.823
Friend suicide a year ago 1.22 0.60-2.49 0.295 0.587
Negative life events half year ago 5.74 3.28-10.04 43.365 0.000
Family emotional support needed 0.43 0.26-0.72 10.587 0.001
Family emotional support gained 1.06 0.72-1.55 0.086 0.769
Friends' emotional support needed 0.38 0.24-0.60 16.025 0.000
Friends' emotional support gained 1.06 0.72-1.55 0.084 0.772
Depression (HDRS = ≥ 35) a 1.58 1.07-2.34 5.227 0.020
Hopelessness (HDRS = ≥ 6) a 7.68 4.99-11.83 93.755 0.000
Anxiety/Somatization(HDRS = > 7) a 0.84 0.56-1.27 0.706 0.401
Loss of weight in a week(= 0.5 kg) 0.93 0.64-1.36 0.149 0.699
Cognitive impairment(HDRS = > 12) a 1.17 0.77-1.78 0.553 0.457
Diurnal change (HDRS = ≥ 1) a 1.12 0.76-1.66 0.350 0.554
Slow movement (HDRS = ≥ 8) a 1.12 1.77-4.64 0.340 0.560
Sleep disorders (HDRS = ≥ 2) a 3.28 2.20-4.88 35.128 0.000
Anxiety (HAMA = ≥ 21) b 4.12 2.54-6.68 35.622 0.000
TPH2 rs7305115 AA 0.50 0.31-0.82 13.941 0.000
  1. a HDRS, Hamilton depression rating scale for depression;
  2. b HAMA, Hamilton anxiety scale for anxiety