From: Effect of Tryptophan Hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression
Variables | OR | 95% CI | Wald | P value |
---|---|---|---|---|
Education under middle school | 2.39 | 1.62-3.52 | 19.705 | 0.000 |
Married | 0.20 | 0.12-0.32 | 46.600 | 0.000 |
Age of onset (= ≥ 35 years) | 0.79 | 0.54-1.17 | 1.407 | 0.236 |
Short course of diseases (= ≤ 1 year) | 0.83 | 0.57-1.21 | 0.943 | 0.332 |
Employed | 0.67 | 0.45-1.00 | 3.809 | 0.051 |
Family history of Mental illness | 0.94 | 0.64-1.39 | 0.086 | 0.769 |
Onset abruptly or subacute | 1.13 | 0.76-1.68 | 0.366 | 0.545 |
Predisposing factors | 1.15 | 0.78-1.72 | 0.500 | 0.479 |
Unhappy childhood | 1.12 | 0.70-1.80 | 0.233 | 0.650 |
Family history of suicide | 2.58 | 1.47-4.54 | 11.328 | 0.001 |
Physical disease | 1.15 | 0.69-1.93 | 0.279 | 0.597 |
Monthly income (= < $40) | 2.02 | 1.37-2.99 | 7.892 | 0.005 |
Smoking | 1.64 | 1.02-2.65 | 4.164 | 0.041 |
Drinking | 1.64 | 1.07-2.53 | 5.178 | 0.023 |
Introversion | 1.90 | 1.25-2.87 | 9.155 | 0.002 |
Economic pressure | 2.58 | 1.64-4.05 | 17.434 | 0.000 |
Unhappy a month ago | 0.96 | 0.65-1.42 | 0.040 | 0.841 |
Unhappy a year ago | 1.14 | 0.76-1.72 | 0.397 | 0.529 |
Unhappy after a year | 0.87 | 0.60-1.31 | 0.362 | 0.547 |
Friend suicide two weeks ago | 1.11 | 0.46-2.66 | 0.050 | 0.823 |
Friend suicide a year ago | 1.22 | 0.60-2.49 | 0.295 | 0.587 |
Negative life events half year ago | 5.74 | 3.28-10.04 | 43.365 | 0.000 |
Family emotional support needed | 0.43 | 0.26-0.72 | 10.587 | 0.001 |
Family emotional support gained | 1.06 | 0.72-1.55 | 0.086 | 0.769 |
Friends' emotional support needed | 0.38 | 0.24-0.60 | 16.025 | 0.000 |
Friends' emotional support gained | 1.06 | 0.72-1.55 | 0.084 | 0.772 |
Depression (HDRS = ≥ 35) a | 1.58 | 1.07-2.34 | 5.227 | 0.020 |
Hopelessness (HDRS = ≥ 6) a | 7.68 | 4.99-11.83 | 93.755 | 0.000 |
Anxiety/Somatization(HDRS = > 7) a | 0.84 | 0.56-1.27 | 0.706 | 0.401 |
Loss of weight in a week(= 0.5 kg) | 0.93 | 0.64-1.36 | 0.149 | 0.699 |
Cognitive impairment(HDRS = > 12) a | 1.17 | 0.77-1.78 | 0.553 | 0.457 |
Diurnal change (HDRS = ≥ 1) a | 1.12 | 0.76-1.66 | 0.350 | 0.554 |
Slow movement (HDRS = ≥ 8) a | 1.12 | 1.77-4.64 | 0.340 | 0.560 |
Sleep disorders (HDRS = ≥ 2) a | 3.28 | 2.20-4.88 | 35.128 | 0.000 |
Anxiety (HAMA = ≥ 21) b | 4.12 | 2.54-6.68 | 35.622 | 0.000 |
TPH2 rs7305115 AA | 0.50 | 0.31-0.82 | 13.941 | 0.000 |