Correlating lesion size and location to deficits after ischemic stroke: the influence of accounting for altered peri-necrotic tissue and incidental silent infarcts

Table 2 Association of motor impairment scores with the mean individual and cumulative lesion volumes for each region

Lesion Type:	Lesion Volume,^a cm³	Correlation Between Impairment Score and Lesion Volume (p-value)^b
Region 1 ^c	15.9 (30.7) 0.09 - 126.2	-0.35 (0.025)*
Region 2 ^d	4.1 (6.6) 0.0 - 28.5	-0.28 (0.10)
Region 3 ^e	0.058 (0.051) 0.0 - 0.17	0.029 (0.86)
Region 4 ^f	0.63 (1.1) 0.0 - 3.9	0.005 (0.98)
Region 1 + 2	19.6 (36.7) 0.12 - 154.7	-0.35 (0.028)*
Region 1 + 2 + 3	19.6 (36.2) 0.12 - 154.7	-0.34 (0.030)*
Region 1 + 2 + 3 + 4	19.9 (36.6) 0.20 - 154.7	-0.34 (0.032)*

Data for entire patient sample (n = 41) is shown
^a Lesion volumes are shown as mean (SD) and range
^b Correlation between mean lesion volume of a Region and Fugl-Meyer motor impairment scores (Values are Spearman rank correlation coefficients, with p-values in brackets)
^c Region 1 represents the lesion core
^d Region 2 represents the peri-necrotic tissue
^e Region 3 represents lesions in the same hemisphere as index stroke
^f Region 4 represents lesions in the opposite hemisphere
* Significant at p < 0.05

ISSN: 1744-9081