Figure 2From: Role of aspartyl-(asparaginyl)-β-hydroxylase mediated notch signaling in cerebellar development and functionEffects of siAAH and pAAH brain transfections on motor performance. P2 Long Evans rat pups were administered intracerebroventricular injections of siRNA targeting AAH (siAAH) or no specific gene (siScr) (A-C), or recombinant plasmid DNA containing the full-length AAH cDNA (pAAH) or GFP (D-F). On P20, rats were subjected to 10 incremental speed trials (from 2 to 10 rpm) of rotarod testing of motor function. The maximum duration of performance was limited to 30 seconds. Data from (A, D) Trials 1-3 (2-4.5 rpm), (B, E) Trials 4-7 (5-7.5 rpm), and (C, F) Trials 8-10 (8-10 rpm) were culled and analyzed using the Mann-Whitney test. Panels display box plots with means and minimum-maximum whiskers. Significant P-values are indicated within the panels.Back to article page