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Figure 2 | Behavioral and Brain Functions

Figure 2

From: Role of aspartyl-(asparaginyl)-β-hydroxylase mediated notch signaling in cerebellar development and function

Figure 2

Effects of siAAH and pAAH brain transfections on motor performance. P2 Long Evans rat pups were administered intracerebroventricular injections of siRNA targeting AAH (siAAH) or no specific gene (siScr) (A-C), or recombinant plasmid DNA containing the full-length AAH cDNA (pAAH) or GFP (D-F). On P20, rats were subjected to 10 incremental speed trials (from 2 to 10 rpm) of rotarod testing of motor function. The maximum duration of performance was limited to 30 seconds. Data from (A, D) Trials 1-3 (2-4.5 rpm), (B, E) Trials 4-7 (5-7.5 rpm), and (C, F) Trials 8-10 (8-10 rpm) were culled and analyzed using the Mann-Whitney test. Panels display box plots with means and minimum-maximum whiskers. Significant P-values are indicated within the panels.

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