TY - JOUR AU - Johansen, Espen Borgå AU - Knoff, Monica AU - Fonnum, Frode AU - Lausund, Per Leines AU - Walaas, S. Ivar AU - Wøien, Grete AU - Sagvolden, Terje PY - 2011 DA - 2011/05/26 TI - Postnatal exposure to PCB 153 and PCB 180, but not to PCB 52, produces changes in activity level and stimulus control in outbred male Wistar Kyoto rats JO - Behavioral and Brain Functions SP - 18 VL - 7 IS - 1 AB - Polychlorinated biphenyls (PCBs) are a class of organic compounds that bioaccumulate due to their chemical stability and lipophilic properties. Humans are prenatally exposed via trans-placental transfer, through breast milk as infants, and through fish, seafood and fatty foods as adolescents and adults. Exposure has several reported effects ranging from developmental abnormalities to cognitive and motor deficiencies. In the present study, three experimental groups of rats were orally exposed to PCBs typically found in human breast milk and then behaviorally tested for changes in measures of stimulus control (percentage lever-presses on the reinforcer-producing lever), activity level (responses with IRTs > 0.67 s), and responses with short IRTs (< 0.67 s). SN - 1744-9081 UR - https://doi.org/10.1186/1744-9081-7-18 DO - 10.1186/1744-9081-7-18 ID - Johansen2011 ER -