Skip to main content

Table 4 Haplotype analysis of IL-1β gene polymorphisms

From: Possible association between Interleukin-1beta gene and schizophrenia in a Japanese population

   

Males

Females

Block

Haplotype

Diagnosis

Carrier

Non-carrier

χ2

Nominal P value

Permutation P value

Carrier

Non-carrier

χ2

Nominal P value

Permutation P value

 

GT

Schizophrenia

336.3

265.7

0.557

0.456

0.957

251.0

213.0

6.240

0.0125

0.118

   

(0.559)

(0.441)

   

(0.541)

(0.459)

   
  

Controls

447.9

326.1

   

901.0

585.0

   
   

(0.579)

(0.421)

   

(0.606)

(0.394)

   

1

GC

Schizophrenia

183.1

418.9

0.216

0.642

0.995

149.0

315.0

2.298

0.130

0.691

   

(0.304)

(0.696)

   

(0.321)

(0.679)

   
  

Controls

226.4

547.6

   

422.5

1063.5

   
   

(0.293)

(0.707)

   

(0.284)

(0.716)

   
 

AC

Schizophrenia

82.6

519.4

0.215

0.643

0.995

63.7

400.3

3.281

0.0701

0.461

   

(0.137)

(0.863)

   

(0.137)

(0.863)

   
  

Controls

99.6

674.4

   

158.5

1327.5

   
   

(0.129)

(0.871)

   

(0.107)

(0.893)

   
 

GG

Schizophrenia

321.4

280.6

0.154

0.694

0.996

231.2

228.8

5.012

0.0252

0.207

   

(0.534)

(0.466)

   

(0.503)

(0.497)

   
  

Controls

422.6

353.4

   

837.4

652.6

   
   

(0.545)

(0.455)

   

(0.562)

(0.438)

   

2

GA

Schizophrenia

183.5

418.5

0.040

0.841

1.00

156.4

303.6

5.326

0.0210

0.178

   

(0.305)

(0.695)

   

(0.340)

(0.660)

   
  

Controls

232.7

543.3

   

422.8

1067.2

   
   

(0.300)

(0.700)

   

(0.284)

(0.716)

   
 

TA

Schizophrenia

97.1

504.9

0.081

0.776

0.999

72.4

387.6

0.027

0.869

1.00

   

(0.161)

(0.839)

   

(0.157)

(0.843)

   
  

Controls

120.7

655.3

   

229.8

1260.2

   
   

(0.156)

(0.844)

   

(0.154)

(0.846)

   
  1. Numbers in parentheses represent the frequencies of haplotypes. Permutation P values were based on 10,000 permutations.