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Table 4 Haplotype analysis of IL-1β gene polymorphisms

From: Possible association between Interleukin-1beta gene and schizophrenia in a Japanese population

    Males Females
Block Haplotype Diagnosis Carrier Non-carrier χ2 Nominal P value Permutation P value Carrier Non-carrier χ2 Nominal P value Permutation P value
  GT Schizophrenia 336.3 265.7 0.557 0.456 0.957 251.0 213.0 6.240 0.0125 0.118
    (0.559) (0.441)     (0.541) (0.459)    
   Controls 447.9 326.1     901.0 585.0    
    (0.579) (0.421)     (0.606) (0.394)    
1 GC Schizophrenia 183.1 418.9 0.216 0.642 0.995 149.0 315.0 2.298 0.130 0.691
    (0.304) (0.696)     (0.321) (0.679)    
   Controls 226.4 547.6     422.5 1063.5    
    (0.293) (0.707)     (0.284) (0.716)    
  AC Schizophrenia 82.6 519.4 0.215 0.643 0.995 63.7 400.3 3.281 0.0701 0.461
    (0.137) (0.863)     (0.137) (0.863)    
   Controls 99.6 674.4     158.5 1327.5    
    (0.129) (0.871)     (0.107) (0.893)    
  GG Schizophrenia 321.4 280.6 0.154 0.694 0.996 231.2 228.8 5.012 0.0252 0.207
    (0.534) (0.466)     (0.503) (0.497)    
   Controls 422.6 353.4     837.4 652.6    
    (0.545) (0.455)     (0.562) (0.438)    
2 GA Schizophrenia 183.5 418.5 0.040 0.841 1.00 156.4 303.6 5.326 0.0210 0.178
    (0.305) (0.695)     (0.340) (0.660)    
   Controls 232.7 543.3     422.8 1067.2    
    (0.300) (0.700)     (0.284) (0.716)    
  TA Schizophrenia 97.1 504.9 0.081 0.776 0.999 72.4 387.6 0.027 0.869 1.00
    (0.161) (0.839)     (0.157) (0.843)    
   Controls 120.7 655.3     229.8 1260.2    
    (0.156) (0.844)     (0.154) (0.846)    
  1. Numbers in parentheses represent the frequencies of haplotypes. Permutation P values were based on 10,000 permutations.