Figure 3

Maternally separated WKY rats showed increased anxiety-like behaviour in the elevated plus maze relative to non-separated WKY controls. Results are displayed as median and interquartile range. a. Time spent in the closed arms of the elevated plus maze grouped by strain and stress and divided into 5 × 1 minute time bins. * SHR spent significantly less time in the closed arms than WKY in all time periods (p < 0.05). ^$Maternally separated WKY rats spent significantly more time in the closed arms than non-separated WKY in the first minute (p < 0.05). b. Latency to enter the open arms of the elevated plus maze grouped by strain and stress. * SHR took a significantly shorter time to enter the open arm than WKY rats (p < 0.0001). ^$Maternally separated WKY rats took significantly longer to enter the open arm of the elevated plus maze than WKY NMS rats (p < 0.05).