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Table 2 Genotype Association of COMT SNP rs165774

From: A novel SNP in COMT is associated with alcohol dependence but not opiate or nicotine dependence: a case control study

Sample

Genotype Counts

 

p-value*

 

AA (%)

AG (%)

GG (%)

 

control

39 (16.25)

98 (40.83)

103 (42.92)

 

Nicotine dependence

21 (14.38)

51 (34.93)

74 (50.69)

0.330

Odds ratio

1

0.966

1.334

0.205†

p-value

 

1.000

0.700

 

Opiate dependence

13 (11.11)

47 (40.17)

57 (48.72)

0.363

Odds ratio

1

1.439

1.660

0.172†

p-value

 

0.626

0.300

 

Alcohol dependence

18 (7.96)

97 (42.92)

111(49.12)

0.022

Odds ratio

1

2.146

2.336

0.023†

p-value

 

0.029

0.012

 
  1. * p-value determined by Pearson's χ2 test (DF = 2)
  2. † p-value determined using the extended Mantel-Haenszel test for trend (DF = 1)
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Behavioral and Brain Functions

ISSN: 1744-9081

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