Table 2 Comparison of genotype and allele frequencies of six SNPs at the NRXN1 gene between schizophrenic patients and healthy control subjects
From: A case-control association study of NRXN1 polymorphisms with schizophrenia in Chinese Han population
Makers | Genotype N (Freq.) | Chi-square (df = 2) | p- value | HWEP | Allele N (Freq.) | Chi-square (df = 1) | p- value | OR (95% CI) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
rs10490168 | AA | AG | GG | Â | Â | Â | A | G | Â | Â | Â |
Cases | 10(0.013) | 173(0.225) | 585(0.762) | 6.049 | 0.048 | 0.485 | 193(0.126) | 1343(0.874) | 5.677 | 0.017 | 0.78(0.63-0.96) |
Controls | 13(0.018) | 204(0.276) | 521(0.706) | Â | Â | 0.168 | 230(0.156) | 1246(0.844) | Â | Â | Â |
rs2024513 | AA | AG | GG | Â | Â | Â | A | G | Â | Â | Â |
Cases | 544(0.708) | 206(0.268) | 18(0.023) | 7.521 | 0.023 | 0.772 | 1294(0.842) | 242(0.158) | 7.327 | 0.006 | 1.30(1.07-1.56) |
Controls | 480(0.650) | 228(0.309) | 30(0.041) | Â | Â | 0.655 | 1188(0.805) | 288(0.195) | Â | Â | Â |
rs10174398 | CC | CT | TT | Â | Â | Â | C | T | Â | Â | Â |
Cases | 276(0.359) | 359(0.467) | 133(0.173) | 0.727 | 0.695 | 0.382 | 911(0.593) | 625(0.407) | 1.064 | 0.397 | 1.06(0.92-1.23) |
Controls | 254(0.344) | 345(0.467) | 139(0.188) | Â | Â | 0.256 | 853(0.578) | 623(0.422) | Â | Â | Â |
rs10195460 | AA | AG | GG | Â | Â | Â | A | G | Â | Â | Â |
Cases | 61(0.079) | 318(0.414) | 389(0.507) | 1.197 | 0.549 | 0.721 | 440(0.286) | 1096(0.714) | 0.972 | 0.323 | 0.92(0.79-1.08) |
Controls | 62(0.084) | 323(0.438) | 353(0.478) | Â | Â | 0.321 | 447(0.303) | 1029(0.697) | Â | Â | Â |
rs13382584 | CC | CT | TT | Â | Â | Â | C | T | Â | Â | Â |
Cases | 14(0.018) | 200(0.260) | 554(0.721) | 7.075 | 0.029 | 0.404 | 228(0.148) | 1308(0.852) | 6.821 | 0.009 | 0.77(0.64-0.94) |
Controls | 23(0.031) | 225(0.305) | 489(0.664) | Â | Â | 0.638 | 271(0.184) | 1203(0.816) | Â | Â | Â |
rs1558852 | AA | AG | GG | Â | Â | Â | A | G | Â | Â | Â |
Cases | 234(0.305) | 383(0.499) | 151(0.197) | 4.666 | 0.097 | 0.799 | 851(0.554) | 685(0.446) | 4.627 | 0.031 | 0.85(0.74-0.99) |
Controls | 259(0.351) | 357(0.484) | 122(0.165) | Â | Â | 0.956 | 875(0.593) | 601(0.407) | Â | Â | Â |