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Figure 2 | Behavioral and Brain Functions

Figure 2

From: Update in the methodology of the chronic stress paradigm: internal control matters

Figure 2

Differential stress-induced changes in the sucrose test parameters in anhedonic and non-anhedonic mice. (A) Sucrose preference in the anhedonic group is significantly lower than in non-anhedonic and control mice after 2.5, 3.5 and 4 weeks of stress. (B) Sucrose intake in the anhedonic group is significantly increased after 2.5 weeks of stress and significantly decreased after 3.5 weeks of stress (vs. non-anhedonic group) and after 4 weeks of stress (vs. control and non-anhedonic group). Non-anhedonic mice show elevated sucrose intake after 2.5 and 3.5 weeks of stress. (C) Water intake is elevated in the anhedonic animals after 2.5 - 4 weeks of stress (vs. control and non-anhedonic group). In the non-anhedonic group; water intake is increased after 2.5 weeks of stress as compared to control. (D) Total liquid intake is elevated both in the anhedonic and in non-anhedonic animals after 2.5 and 3.5 weeks of stress (vs. control group). After 2.5 weeks, anhedonic mice show significantly higher total liquid intake than non-anhedonic mice. Parameters of the sucrose test are expressed as a percentage of the mean values of the control group, and compared between anhedonic (dashed line) and non-anhedonic (plain line) groups during a 4-week stress procedure as mean ± (SEM) (*p < 0.05 vs. control group; #p < 0.05 vs. non-anhedonic group; Mann-Whitney).

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