Update in the methodology of the chronic stress paradigm: internal control matters

Table 1 Partial depressive-like outcomes in chronic stress models of depression

Stress	Laboratory strain	Measure of a depressive-like state	Susceptibility rate	Reference
6-week CMS	Wistar rats	Low sucrose preference	51.5%	[25]
5-week social stress	CD1 mice	Increase of CORT, Low sucrose preference	20%	[24, 57]
7-week CMS	Wistar rats	Low sucrose intake	50-70%	[23, 54–56]
10-day social defeat	C57BL/6J	Social avoidance, Low sucrose preference	50-70%	[21, 50–53, 58]
7-week unpredictable CMS	Eleven common mouse strains	Coat deterioration, Low sucrose preference	Vary in different strains	[22, 41, 60]

Recent studies identified susceptible and resilient subpopulations of chronically stressed mice defined by anhedonia occurrence in a sucrose test, deterioration of a coat state, or an increase in basal CORT levels.

ISSN: 1744-9081