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Table 5 Effects of COX-2 inhibitor in mice subjected to chronic stress

From: Update in the methodology of the chronic stress paradigm: internal control matters

Changes versus non-stressed control Stressed drug naive Stressed Citalopram-treated Stressed treated with COX-2 blocker
Sucrose preference
Sucrose intake
Floating behavior
Contextual fear conditioning
Parameters of anxiety in elevated O-maze
Percentage of anhedonic mice above 60% below 25% below 25%
  1. Chronic treatment with a COX-2 inhibitor during the course of chronic stress counteracted the development of hedonic deficit, behavioural despair, increased anxiety and cognitive impairment in a similar manner to citalopram. Arrows indicate an increase in the parameter (↑), a decrease (↓), or lack of significant changes in comparison to non-stressed control mice (↔).