CRS-exposed mice exhibit a decreased appetitive response, and fail to avoid a mildly aversive stimulus. (a) Preference ratios for saccharin versus water in control and CRS-exposed mice in Group 1 (see Figure 1). Shaded area denotes CRS exposure. (b) Preference ratio for quinine versus water in control and CRS-exposed mice. (c) Control animals gain significantly more weight than CRS-exposed animals over the course of the experiment, while CRS animals do not gain a significant amount of weight and weigh significantly less than controls after CRS-exposure. (d) Increased adrenal weight in CRS-exposed animals; presented as % of total body weight. CRS exposure leads to decreased thymus weight. (f) CRS exposure leads to a decreased testes weight. Results here and in subsequent figures are reported as mean ± SEM; * = p < 0.05, ** = p < 0.01 and *** = p < 0.001.