Figure 8

Treatment with the AChE-I, phenserine provides a partial recovery for CRS-induced deficits in immediate early gene activation following exposure to a motivational stimulus. (a) Control animals (no CRS), injected with saline and exposed to a Q-tip dipped in estrous urine (hatched bars) show significantly increased numbers of c-fos positive nuclei in the medial preoptic area (MPO) as compared to those exposed to a Q-tip dipped in water (white bars). CRS animals administered either saline (black bars) or phenserine (grey bars) do not show an increase in c-fos positive nuclei after sniffing on estrous urine. (b) Control animals (no CRS), injected with saline and exposed to a Q-tip dipped in estrous urine (hatched bars) show significantly increased numbers of c-fos positive nuclei in the LS as compared to those exposed to a Q-tip dipped in water (white bars). CRS-exposed animals administered either saline (black bars) or phenserine (grey bars) do not show an increase in c-fos positive nuclei after sniffing on estrous urine. (c) Control animals (no CRS), injected with saline and exposed to a Q-tip dipped in estrous urine (hatched bars) show significantly increased numbers of c-fos positive nuclei in the MS as compared to those exposed to a Q-tip dipped in water (white bars). CRS-exposed animals administered saline (black bars) do not show an increase in c-fos positive nuclei after sniffing on estrous urine. CRS-exposed animals administered phenserine (grey bars) partially recover the induction in c-fos positive nuclei following estrous urine exposure. (d) Control animals (no CRS), injected with saline and exposed to a Q-tip dipped in estrous urine (hatched bars) show significantly increased numbers of c-fos positive nuclei in the NAcc as compared to those exposed to a Q-tip dipped in water (white bars). CRS animals administered saline (black bars) do not show an increase in c-fos positive nuclei after sniffing on estrous urine. CRS-exposed animals administered phenserine (grey bars) fully recover the induction in c-fos positive nuclei following estrous urine exposure. (e) Control animals (no CRS), injected with saline and exposed to a Q-tip dipped in estrous urine (hatched bars) show significantly increased numbers of c-fos positive nuclei in the PrL as compared to those exposed to a Q-tip dipped in water (white bars). CRS animals administered either saline (black bars) or phenserine (grey bars) do not show an increase in c-fos positive nuclei after sniffing on estrous urine.