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Table 4 Logistic regression analysis of 5HTTLPR gene and 5HT1B receptor gene G861C polymorphism and their interaction for the risk of antisocial alcoholism (AS-ALC)

From: Interaction between Serotonin Transporter and Serotonin Receptor 1 B genes polymorphisms may be associated with antisocial alcoholism

  AS-ALC
Models B OR 95% CI P-value
Model 1     
5HTTLPR low functional group −0.47 0.62 0.22-1.75 0.37
5HT1B G861C G/C −0.21 0.81 0.29-2.27 0.69
5HT1B G861C C/C −1.13 0.32 0.07-1.46 0.14
5HTTLPR low-functional group*5HT1B G861C G/C 1.09 2.97 0.84-10.44 0.09
5HTTLPR low-functional group*5HT1B G861C C/C 1.83 6.22 1.10-35.27 0.04*
Model 2     
5HTTLPR low-functional group 0.14 1.15 0.43-3.07 0.78
5HT1B G861C G/C 0.49 1.63 0.61-4.35 0.33
5HT1B G861C C/C −1.26 0.28 0.07-1.19 0.09
5HTTLPR low-functional group*5HT1B G861C G/C 0.07 1.07 0.32-3.65 0.91
5HTTLPR low-functional group*5HT1B G861C C/C 1.75 5.76 1.09-30.44 0.04*
  1. 5HTTLPR low-functional group: S/S, S/L G , L G /L G
  2. 5HTTLPR high-functional group: S/L A , L G /L A , L A /L A , S/XL, L A /XL, L G /XL
  3. B, coefficients; CI, confidence interval; OR, odds ratio
  4. Model 1, reference groups are: 5HTTLPR high-functional group, 5HT1B G861C G/G genotypes, and AS-N-ALC group; covarying for age
  5. Model 2, reference groups are: 5HTTLPR high-functional group, 5HT1B G861C G/G genotypes, and controls; covarying for age
  6. *P < 0.05.
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