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Table 2 Marker genotype frequencies at the DRD2 and PPP1R1B loci in the comparison group and males with ASD from affected sib-pair families 1

From: DRD2 and PPP1R1B (DARPP-32) polymorphisms independently confer increased risk for autism spectrum disorders and additively predict affected status in male-only affected sib-pair families

DRD2    Genotype     FDR threshold2
rs1799732 N Ins/Ins Del/Ins Del/Del χ2 (df = 2) P 1  
 Comparison group 238 188 (79.0%) 46 (19.3%) 4 (1.7%)    
 Affected males3 109 89 (81.7%) 16 (14.7%) 4 (3.7%) 2.253 0.32 0.025
rs1079597 N G/G A/G A/A χ2 (df = 2) P  
 Comparison group 244 168 (68.9%) 71 (29.1%) 5 (2.0%)    
 Affected males3 105 70 (66.7%) 30 (28.6%) 5 (4.8%) 1.944 0.38 0.038
rs1800498 N T/T C/T C/C χ2 (df = 2) P  
 Comparison group 244 70 (28.7%) 130 (53.3%) 44 (18.0%)    
 Affected males3 106 46 (43.4%) 38 (35.8%) 22 (20.8%) 9.790 0.007 0.013
rs1800497 N C/C T/C T/T χ2 (df = 2) P  
 Comparison group 245 164 (66.9%) 69 (28.2%) 12 (4.9%)    
 Affected males3 107 65 (60.7%) 35 (32.7%) 7 (6.5%) 1.333 0.51 0.050
PPP1R1B   Genotype    FDR threshold 2
rs1495099 N C/C C/G G/G χ2 (df = 2) P 1  
 Comparison group 434 43 (9.9%) 163 (37.6%) 228 (52.5%)    
 Affected males3 109 24 (22.0%) 39 (35.8%) 46 (42.2%) 12.273 0.002 0.0083
rs907094 N C/C C/T T/T χ2 (df = 2) P  
 Comparison group 434 30 (6.9%) 146 (33.6%) 258 (59.4%)    
 Affected males3 110 16 (14.5%) 38 (34.5%) 56 (50.9%) 7.176 0.028 0.033
rs3764352 N G/G A/G A/A χ2 (df = 2) P  
 Comparison group 434 29 (6.7%) 152 (35.0%) 253 (58.3%)    
 Affected males3 110 16 (14.5%) 38 (34.5%) 56 (50.9%) 7.408 0.025 0.025
  1. 1P-values less than 0.05 are in bold and P-values which remain significant following false-discovery rate (FDR) corrections for multiple comparisons are underlined
  2. 2P-value ≤ FDR threshold is significant
  3. 3One affected individual was randomly chosen from each family