Table 2 Marker genotype frequencies at the DRD2 and PPP1R1B loci in the comparison group and males with ASD from affected sib-pair families ¹

N

Ins/Ins

Del/Ins

Del/Del

χ² (df = 2)

P ¹

238

188 (79.0%)

46 (19.3%)

4 (1.7%)

109

89 (81.7%)

16 (14.7%)

4 (3.7%)

2.253

0.32

0.025

N

G/G

A/G

A/A

χ² (df = 2)

P

244

168 (68.9%)

71 (29.1%)

5 (2.0%)

105

70 (66.7%)

30 (28.6%)

5 (4.8%)

1.944

0.38

0.038

N

T/T

C/T

C/C

χ² (df = 2)

P

244

70 (28.7%)

130 (53.3%)

44 (18.0%)

106

46 (43.4%)

38 (35.8%)

22 (20.8%)

9.790

0.007

0.013

N

C/C

T/C

T/T

χ² (df = 2)

P

245

164 (66.9%)

69 (28.2%)

12 (4.9%)

107

65 (60.7%)

35 (32.7%)

7 (6.5%)

1.333

0.51

0.050

Genotype

FDR threshold ²

N

C/C

C/G

G/G

χ² (df = 2)

P ¹

434

43 (9.9%)

163 (37.6%)

228 (52.5%)

109

24 (22.0%)

39 (35.8%)

46 (42.2%)

12.273

0.002

0.0083

N

C/C

C/T

T/T

χ² (df = 2)

P

434

30 (6.9%)

146 (33.6%)

258 (59.4%)

110

16 (14.5%)

38 (34.5%)

56 (50.9%)

7.176

0.028

0.033

N

G/G

A/G

A/A

χ² (df = 2)

P

434

29 (6.7%)

152 (35.0%)

253 (58.3%)

110

16 (14.5%)

38 (34.5%)

56 (50.9%)

7.408

0.025

0.025