Skip to main content

Table 3 FBAT of marker allele transmissions under an additive model at the DRD2 locus and FBAT of marker allele transmissions under a recessive model at the PPP1R1B locus in affected sib-pair families 1

From: DRD2 and PPP1R1B (DARPP-32) polymorphisms independently confer increased risk for autism spectrum disorders and additively predict affected status in male-only affected sib-pair families

DRD2

# Fam

Observed

Expected

Z

P 2

FDR threshold3

rs1799732

      

Ins

31

90.0

84.0

1.4

0.16

0.030

Del

31

38.0

44.0

−1.4

0.16

 

rs1079597

      

G

56

149.0

148.0

0.17

0.86

0.040

A

56

71.0

72.0

−0.17

0.86

 

rs1800498

      

T

73

185.0

160.0

3.6

0.0003

0.010

C

73

115.0

140.0

−3.6

0.0003

 

rs1800497

      

C

63

171.0

170.5

0.08

0.94

0.050

T

63

89.0

89.5

−0.08

0.94

 

PPP1R1B

# Fam

Observed

Expected

Z

P 2

FDR threshold 3

rs1495099

      

G

52

42.0

43.8

−0.4

0.72

0.043

C

34

39.0

26.3

3.3

0.00092

0.0071

rs907094

      

T

52

46.0

48.3

−0.5

0.66

0.036

C

24

25.0

19.8

1.6

0.11

0.029

rs3764352

      

A

54

48.0

49.8

−0.3

0.73

0.050

G

26

27.0

21.3

1.7

0.09

0.021

  1. 1All affected individuals were included in the analyses.
  2. 2P-values less than 0.05 are in bold and P-values which remain significant following false-discovery rate (FDR) corrections for multiple comparisons are underlined.
  3. 3P-value ≤ FDR threshold is significant.