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Table 3 FBAT of marker allele transmissions under an additive model at the DRD2 locus and FBAT of marker allele transmissions under a recessive model at the PPP1R1B locus in affected sib-pair families 1

From: DRD2 and PPP1R1B (DARPP-32) polymorphisms independently confer increased risk for autism spectrum disorders and additively predict affected status in male-only affected sib-pair families

DRD2 # Fam Observed Expected Z P 2 FDR threshold3
rs1799732       
Ins 31 90.0 84.0 1.4 0.16 0.030
Del 31 38.0 44.0 −1.4 0.16  
rs1079597       
G 56 149.0 148.0 0.17 0.86 0.040
A 56 71.0 72.0 −0.17 0.86  
rs1800498       
T 73 185.0 160.0 3.6 0.0003 0.010
C 73 115.0 140.0 −3.6 0.0003  
rs1800497       
C 63 171.0 170.5 0.08 0.94 0.050
T 63 89.0 89.5 −0.08 0.94  
PPP1R1B # Fam Observed Expected Z P 2 FDR threshold 3
rs1495099       
G 52 42.0 43.8 −0.4 0.72 0.043
C 34 39.0 26.3 3.3 0.00092 0.0071
rs907094       
T 52 46.0 48.3 −0.5 0.66 0.036
C 24 25.0 19.8 1.6 0.11 0.029
rs3764352       
A 54 48.0 49.8 −0.3 0.73 0.050
G 26 27.0 21.3 1.7 0.09 0.021
  1. 1All affected individuals were included in the analyses.
  2. 2P-values less than 0.05 are in bold and P-values which remain significant following false-discovery rate (FDR) corrections for multiple comparisons are underlined.
  3. 3P-value ≤ FDR threshold is significant.