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Table 5 General discriminant analysis of DRD2 rs1800498 and PPP1R1B rs1495099 genotypes towards prediction of ASDs in affected males 1

From: DRD2 and PPP1R1B (DARPP-32) polymorphisms independently confer increased risk for autism spectrum disorders and additively predict affected status in male-only affected sib-pair families

  Eigenvalue Canonical R Wilk’s Lambda χ2 F2 df P 3 FDR threshold4
DRD2 - PPP1R1B 0.07 0.26 0.94 23.27 4 0.00011 0.017
DRD2    0.97 5.14 343 0.0063 0.050
PPP1R1B    0.96 7.20 343 0.00086 0.033
  1. 1One affected individual was randomly chosen from each family
  2. 2Chi-statistic reported for additive test of DRD2 and PPP1R1B and F statistic reported for single gene tests
  3. 3P-values less than 0.05 are in bold and P-values which remain significant following false-discovery rate (FDR) corrections for multiple comparisons are underlined.
  4. 4P-value ≤ FDR threshold is significant