DRD2 and PPP1R1B (DARPP-32) polymorphisms independently confer increased risk for autism spectrum disorders and additively predict affected status in male-only affected sib-pair families

Table 5 General discriminant analysis of DRD2 rs1800498 and PPP1R1B rs1495099 genotypes towards prediction of ASDs in affected males ¹

	Eigenvalue	Canonical R	Wilk’s Lambda	χ² F²	df	P ³	FDR threshold⁴
DRD2 - PPP1R1B	0.07	0.26	0.94	23.27	4	0.00011	0.017
DRD2			0.97	5.14	343	0.0063	0.050
PPP1R1B			0.96	7.20	343	0.00086	0.033

¹One affected individual was randomly chosen from each family
²Chi-statistic reported for additive test of DRD2 and PPP1R1B and F statistic reported for single gene tests
³P-values less than 0.05 are in bold and P-values which remain significant following false-discovery rate (FDR) corrections for multiple comparisons are underlined.
⁴P-value ≤ FDR threshold is significant

ISSN: 1744-9081