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Table 1 Allele frequencies and genotype distribution of SNPs on the SAP97 gene

From: Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia

 

Allele (1/2)a

   

Genotype Frequency (%)

p value

Allele Frequency (%)

p value

  

Sex

Group

HWE

1/1

1/2

2/2

Dom

Rec

Codom

1

2

Allelic

SNP I-2 rs382579

T/C

M

CTL

1

130 (61.6)

71 (33.6)

10 (4.7)

0.675

0.561

0.744

331 (78.4)

91 (21.6)

0.470

   

SCZ

0.718

136 (58.6)

82 (35.3)

14 (6.0)

   

354 (76.3)

110 (23.7)

 
  

F

CTL

1

116 (63.7)

59 (32.4)

7 (3.8)

0.776

0.910

0.939

291 (79.9)

73 (20.1)

0.848

   

SCZ

0.801

104 (64.6)

52 (32.3)

5 (3.1)

   

260 (80.7)

62 (19.3)

 
  

All

CTL

1

246 (62.6)

130 (33.1)

17 (4.3)

0.865

0.714

0.884

622 (79.1)

164 (20.9)

0.667

   

SCZ

1

240 (61.1)

134 (34.1)

19 (4.8)

   

614 (78.1)

172 (21.9)

 

SNP I-3 rs9843659

T/C

M

CTL

0.083

86 (40.8)

88 (41.7)

37 (17.5)

0.545

0.037

0.101

260 (61.6)

162 (38.4)

0.076

   

SCZ

1

72 (31.0)

114 (49.1)

46 (19.8)

   

258 (55.6)

206 (44.4)

 
  

F

CTL

0.755

70 (38.5)

84 (46.2)

28 (15.4)

0.769

1

0.946

224 (61.5)

140 (38.5)

0.814

   

SCZ

0.512

61 (37.9)

73 (45.3)

27 (16.8)

   

195 (60.6)

127 (39.4)

 
  

All

CTL

0.137

156 (39.7)

172 (43.8)

65 (16.5)

0.512

0.104

0.230

484 (61.6)

302 (38.4)

0.123

   

SCZ

0.607

133 (33.8)

187 (47.6)

73 (18.6)

   

453 (57.6)

333 (42.4)

 

SNP I-4 rs2122824

G/T

M

CTL

1

126 (59.7)

75 (35.5)

10 (4.7)

0.538

0.501

0.650

327 (77.5)

95 (22.5)

0.430

   

SCZ

0.861

131 (56.5)

86 (37.1)

15 (6.5)

   

348 (75.0)

116 (25.0)

 
  

F

CTL

1

113 (62.1)

61 (33.5)

8 (4.4)

0.583

1

0.834

287 (78.8)

77 (21.2)

0.851

   

SCZ

0.477

100 (62.1)

56 (34.8)

5 (3.1)

   

256 (79.5)

66 (20.5)

 
  

All

CTL

0.883

239 (60.8)

136 (34.6)

18 (4.6)

0.868

0.611

0.846

614 (78.1)

172 (21.9)

0.587

   

SCZ

0.887

231 (58.8)

142 (36.1)

20 (5.1)

   

604 (76.8)

182 (23.2)

 

SNP I-5 rs7650753

G/T

M

CTL

1

126 (59.7)

75 (35.5)

10 (4.7)

0.419

0.63

0.629

327 (77.5)

95 (22.5)

0.430

   

SCZ

0.597

133 (57.3)

83 (35.8)

16 (6.9)

   

349 (75.2)

115 (24.8)

 
  

F

CTL

1

112 (61.5)

62 (34.1)

8 (4.4)

0.583

1

0.851

286 (78.6)

78 (21.4)

0.779

   

SCZ

0.477

100 (62.1)

56 (34.8)

5 (3.1)

   

256 (79.5)

66 (20.5)

 
  

All

CTL

0.883

238 (60.6)

137 (34.9)

18 (4.6)

0.743

0.771

0.855

613 (78.0)

173 (22.0)

0.673

   

SCZ

1

233 (59.3)

139 (35.4)

21 (5.3)

   

605 (77.0)

181 (23.0)

 

SNP I-10 rs7638423

A/G

M

CTL

0.123

98 (46.4)

84 (39.8)

29 (13.7)

0.892

0.504

0.773

280 (66.4)

142 (33.6)

0.572

   

SCZ

0.316

100 (43.1)

99 (42.7)

33 (14.2)

   

299 (64.4)

165 (35.6)

 
  

F

CTL

0.610

86 (47.3)

76 (41.8)

20 (11.0)

0.866

0.231

0.431

248 (68.1)

116 (31.9)

0.294

   

SCZ

0.731

65 (40.4)

77 (47.8)

19 (11.8)

   

207 (64.3)

115 (35.7)

 
  

All

CTL

0.137

184 (46.8)

160 (40.7)

49 (12.5)

0.831

0.196

0.394

528 (67.2)

258 (32.8)

0.264

   

SCZ

0.660

165 (42.0)

176 (44.8)

52 (13.2)

   

506 (64.4)

280 (35.6)

 

SNP II-1 rs6805920

C/A

M

CTL

0.166

98 (46.4)

85 (40.3)

28 (13.3)

0.784

0.390

0.675

281 (66.6)

141 (33.4)

0.438

   

SCZ

0.395

98 (42.2)

101 (43.5)

33 (14.2)

   

297 (64.0)

167 (36.0)

 
  

F

CTL

0.610

86 (47.3)

76 (41.8)

20 (11.0)

0.737

0.231

0.440

248 (68.1)

116 (31.9)

0.259

   

SCZ

0.865

65 (40.4)

76 (47.2)

20 (12.4)

   

206 (64.0)

116 (36.0)

 
  

All

CTL

0.170

184 (46.8)

161 (41.0)

48 (12.2)

0.670

0.151

0.324

529 (67.3)

257 (32.7)

0.184

   

SCZ

0.662

163 (41.5)

177 (45.0)

53 (13.5)

   

503 (64.0)

283 (36.0)

 

SNP II-8 rs4916461

A/C

M

CTL

0.080

104 (49.3)

80 (37.9)

27 (12.8)

0.679

0.505

0.736

288 (68.2)

134 (31.8)

0.572

   

SCZ

0.108

106 (45.7)

93 (40.1)

33 (14.2)

   

305 (65.7)

159 (34.3)

 
  

F

CTL

0.491

88 (48.4)

74 (40.7)

20 (11.0)

1

0.278

0.490

250 (68.7)

114 (31.3)

0.415

   

SCZ

0.861

68 (42.2)

75 (46.6)

18 (11.2)

   

211 (65.5)

111 (34.5)

 
  

All

CTL

0.079

192 (48.9)

154 (39.2)

47 (12.0)

0.746

0.224

0.453

538 (68.4)

248 (31.6)

0.260

   

SCZ

0.314

174 (44.3)

168 (42.7)

51 (13.0)

   

516 (65.6)

270 (34.4)

 
  1. SNP, single-nucleotide polymorphism; HWE, Hardy-Weinberg equilibrium; M, male; F, female; All, male and female combined; CTL, control; SCZ, schizophrenia; Dom, dominant model; Rec, Recessive model; Codom, Co-dominant model.
  2. Bold values indicate significance level p < 0.05.
  3. aAllele 1 and 2 represent the major and minor alleles of each SNP.
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Behavioral and Brain Functions

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