Figure 3

Effects of acute and chronic administration of baclofen on locomotor activity in rat. Rats were exposed to saline or baclofen (1.25, 2.5, 5 mg/kg, s.c.) for 8 continuous days. On days 1(a) and 8 (b), the rats were administered saline or baclofen and then put into the test chambers to monitor the locomotor activity for 3 h. Data are expressed as the means ± S.E.M. (n = 8 per group).