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Table 1 Demographic and clinical characteristics of ADHD subjects according to G1287A and A-3081T genotypes of SLC6A2

From: Possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder

 

G1287A

A-3081T

 

GG (n = 31)

AG + AA (n = 22)

  

AA (n = 13)

AT + TT (n = 40)

  
 

N (%)

N (%)

X 2

p-value

N (%)

N (%)

X 2

p-value

Sex

  

0.06

>0.99

  

0.39

0.662

 Male

26 (83.9)

19 (86.4)

  

12 (92.3)

33 (82.5)

  

 Female

5 (16.1)

3 (13.6)

  

1 (7.7)

7 (17.5)

  

ADHD subtype

  

4.67

0.097

  

3.87

0.145

 Combined

23 (74.2)

13 (59.1)

  

6 (46.2)

30 (75.0)

  

 Inattentive

8 (25.8)

6 (27.3)

  

6 (46.2)

8 (20.0)

  

 Hyperactive-impulsive

0 (0)

3 (13.6)

  

1 (7.7)

2 (5.0)

  

Comorbidity

        

 ODD

2 (6.5)

4 (18.2)

1.76

0.219

0

6 (15.0)

2.20

0.317

 Anxiety disorder

4 (12.9)

3 (13.6)

0.01

>0.99

1 (7.7)

6 (15.0)

0.46

0.667

 Tic disorder

1 (3.2)

1 (4.5)

0.06

>0.99

1 (7.7)

1 (2.5)

0.73

0.434

 Enuresis

2 (6.5)

0

1.48

0.505

1 (7.7)

1 (2.5)

0.73

0.434

 

Mean (SD)

Mean (SD)

t

p-value

Mean (SD)

Mean (SD)

t

p-value

Age

9.01 (1.96)

9.12 (1.99)

−0.19

0.848

9.26 (2.06)

8.45 (1.47)

1.31

0.198

IQ

108.74 (14.25)

109.27 (11.54)

−0.14

0.886

109.42 (14.90)

108.83 (12.69)

0.16

0.876

ADHD-RS, total

28.45 (10.60)

28.18 (9.97)

0.09

0.926

24.92 (13.28)

29.45 (8.98)

−1.40

0.169

Inattentive

16.13 (6.38)

15.27 (5.22)

0.52

0.607

14.31 (6.92)

16.25 (5.53)

−1.03

0.306

Hyperactive-impulsive

12.32 (5.49)

12.91 (6.52)

−0.35

0.725

10.62 (7.58)

13.20 (5.18)

−1.39

0.171

Mean dose, mg/kg

0.86 (0.33)

0.86 (0.25)

−0.01

0.996

0.78 (0.31)

0.89 (0.28)

−1.10

0.277

  1. Abbreviations: ADHD attention-deficit hyperactivity disorder, ADHD-RS ADHD-Rating Scale.