Skip to main content

Table 1 Demographic and clinical characteristics of ADHD subjects according to G1287A and A-3081T genotypes of SLC6A2

From: Possible effect of norepinephrine transporter polymorphisms on methylphenidate-induced changes in neuropsychological function in attention-deficit hyperactivity disorder

  G1287A A-3081T
  GG (n = 31) AG + AA (n = 22)    AA (n = 13) AT + TT (n = 40)   
  N (%) N (%) X 2 p-value N (%) N (%) X 2 p-value
Sex    0.06 >0.99    0.39 0.662
 Male 26 (83.9) 19 (86.4)    12 (92.3) 33 (82.5)   
 Female 5 (16.1) 3 (13.6)    1 (7.7) 7 (17.5)   
ADHD subtype    4.67 0.097    3.87 0.145
 Combined 23 (74.2) 13 (59.1)    6 (46.2) 30 (75.0)   
 Inattentive 8 (25.8) 6 (27.3)    6 (46.2) 8 (20.0)   
 Hyperactive-impulsive 0 (0) 3 (13.6)    1 (7.7) 2 (5.0)   
Comorbidity         
 ODD 2 (6.5) 4 (18.2) 1.76 0.219 0 6 (15.0) 2.20 0.317
 Anxiety disorder 4 (12.9) 3 (13.6) 0.01 >0.99 1 (7.7) 6 (15.0) 0.46 0.667
 Tic disorder 1 (3.2) 1 (4.5) 0.06 >0.99 1 (7.7) 1 (2.5) 0.73 0.434
 Enuresis 2 (6.5) 0 1.48 0.505 1 (7.7) 1 (2.5) 0.73 0.434
  Mean (SD) Mean (SD) t p-value Mean (SD) Mean (SD) t p-value
Age 9.01 (1.96) 9.12 (1.99) −0.19 0.848 9.26 (2.06) 8.45 (1.47) 1.31 0.198
IQ 108.74 (14.25) 109.27 (11.54) −0.14 0.886 109.42 (14.90) 108.83 (12.69) 0.16 0.876
ADHD-RS, total 28.45 (10.60) 28.18 (9.97) 0.09 0.926 24.92 (13.28) 29.45 (8.98) −1.40 0.169
Inattentive 16.13 (6.38) 15.27 (5.22) 0.52 0.607 14.31 (6.92) 16.25 (5.53) −1.03 0.306
Hyperactive-impulsive 12.32 (5.49) 12.91 (6.52) −0.35 0.725 10.62 (7.58) 13.20 (5.18) −1.39 0.171
Mean dose, mg/kg 0.86 (0.33) 0.86 (0.25) −0.01 0.996 0.78 (0.31) 0.89 (0.28) −1.10 0.277
  1. Abbreviations: ADHD attention-deficit hyperactivity disorder, ADHD-RS ADHD-Rating Scale.
\